Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats

Yu, Daojiang; Li, Shan; Wang, Shuai; Li, Xiujie; Zhu, Min–Sheng; Huang, Shai; Sun, Li; Zhang, Yongsheng; Li, Yanli; Wang, Shouli

doi:10.3390/md14100182

Cited by 16 publications

(5 citation statements)

References 24 publications

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“…VEGF is a mitotic stimulator and chemotactic factor specific to endothelial cells. As an important regulator of angiogenesis, VEGF can activate vascular endothelial cells, improve local vascular permeability, promote the formation of new blood vessels and play an important role in wound healing and tissue reconstruction [ 20 , 30 ]. This study found that, after exposure of HUVECs to different culture conditions, the content of TGF-β1 in the collagen-chitosan mixed solution was significantly higher than that in each single solution, and that in each single solution was significantly higher than the control.…”

Section: Discussionmentioning

confidence: 99%

Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing

Jiang

et al. 2020

Regenerative Biomaterials

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Effective coverage and protection is a priority in wound treatment. Collagen and chitosan have been widely used for wound dressings due to their excellent biological activity and biocompatibility. Silver nanoparticles (AgNPs) have a powerful antibacterial effect. In this study, a macromolecular and small-molecular collagen mixed solution, a macromolecular and small-molecular chitosan mixed solution were prepared, and a silver nanoparticle-loaded collagen-chitosan dressing (AgNP-CCD) has been proposed. First, the effects of a collagen-chitosan mixed solution on the proliferation of human umbilical vein endothelial cells and the secretion of cytokines were evaluated. Then, the characteristics and antibacterial effects of the AgNP-CCD were tested, and the effects on wound healing and the influence of wound cytokine expression were investigated via a deep second-degree burn wound model. The results showed that at the proper proportion and concentration, the collagen-chitosan mixed solution effectively promoted cell proliferation and regulated the levels of growth factors (vascular endothelial growth factor [VEGF], epidermal growth factor [EGF], platelet-derived growth factor [PDGF], transforming growth factor [TGF-β1], basic fibroblastic growth factor [bFGF]) and inflammatory factors (TNF-α, IL-1β, IL-6, IL-8). Moreover, AgNP solutions at lower concentrations exerted limited inhibitory effects on cell proliferation and had no effect on cytokine secretion. The AgNP-CCD demonstrated satisfactory morphological and physical properties as well as efficient antibacterial activities. An in vivo evaluation indicated that AgNP-CCD could accelerate the healing process of deep second-degree burn wounds and played an important role in the regulation of growth and inflammatory factors, including VEGF, EGFL-7, TGF-β1, bFGF, TNF-α and IL-1β. This AgNP-CCD exerted excellent biological effects on wound healing promotion and cytokine expression regulation.

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Section: Discussionmentioning

confidence: 99%

Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing

Jiang

et al. 2020

Regenerative Biomaterials

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“…developed VEGF chitosan nanoparticles by combining chitosan nanoparticles with vascular endothelial growth factor (VEGF) to improve local microcirculation and enhance the protective effect on vascular endothelial cells and skin injury. [ 167,168 ] As more and more successful attempts to use intrinsic nanomaterials for radiation protection arise, we believe that there is still much space left for acquiring more innovations in this interesting and promising area.…”

Section: Research Status Of Intrinsic Nano‐radioprotectantsmentioning

confidence: 99%

Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

Guo¹,

Zhao

Shang

et al. 2023

Exploration

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Ionizing radiation (IR) poses a growing threat to human health, and thus ideal radioprotectors with high efficacy and low toxicity still receive widespread attention in radiation medicine. Despite significant progress made in conventional radioprotectants, high toxicity, and low bioavailability still discourage their application. Fortunately, the rapidly evolving nanomaterial technology furnishes reliable tools to address these bottlenecks, opening up the cutting‐edge nano‐radioprotective medicine, among which the intrinsic nano‐radioprotectants characterized by high efficacy, low toxicity, and prolonged blood retention duration, represent the most extensively studied class in this area. Herein, we made the systematic review on this topic, and discussed more specific types of radioprotective nanomaterials and more general clusters of the extensive nano‐radioprotectants. In this review, we mainly focused on the development, design innovations, applications, challenges, and prospects of the intrinsic antiradiation nanomedicines, and presented a comprehensive overview, in‐depth analysis as well as an updated understanding of the latest advances in this topic. We hope that this review will promote the interdisciplinarity across radiation medicine and nanotechnology and stimulate further valuable studies in this promising field.

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“…IR can kill tumor cells by generating free radicals or ROS ( 157 ). Tumor cells or tumor stem cells resistant to radiotherapy often maintain low levels of ROS and have strong anti-oxidative stress effects ( 158 ).…”

Section: Hdacs and Radiotherapy Resistancementioning

confidence: 99%

HDAC-an important target for improving tumor radiotherapy resistance

et al. 2023

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Radiotherapy is an important means of tumor treatment, but radiotherapy resistance has been a difficult problem in the comprehensive treatment of clinical tumors. The mechanisms of radiotherapy resistance include the repair of sublethal damage and potentially lethal damage of tumor cells, cell repopulation, cell cycle redistribution, and reoxygenation. These processes are closely related to the regulation of epigenetic modifications. Histone deacetylases (HDACs), as important regulators of the epigenetic structure of cancer, are widely involved in the formation of tumor radiotherapy resistance by participating in DNA damage repair, cell cycle regulation, cell apoptosis, and other mechanisms. Although the important role of HDACs and their related inhibitors in tumor therapy has been reviewed, the relationship between HDACs and radiotherapy has not been systematically studied. This article systematically expounds for the first time the specific mechanism by which HDACs promote tumor radiotherapy resistance in vivo and in vitro and the clinical application prospects of HDAC inhibitors, aiming to provide a reference for HDAC-related drug development and guide the future research direction of HDAC inhibitors that improve tumor radiotherapy resistance.

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Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats

Cited by 16 publications

References 24 publications

Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing

Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing

Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

HDAC-an important target for improving tumor radiotherapy resistance

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