Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special reference to an interpretation of renewal cell system.

Yoshimura, Fujio; Soji, Tśuyoshi; Sato, Shigenori; Yokoyama, Masao

doi:10.1507/endocrj1954.24.435

Cited by 101 publications

(56 citation statements)

References 6 publications

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“…In the postnatal development of the anterior pituitary gland, FS cells are reported to act as stem and proliferative progenitor cells (Yoshimura et al 1977, Horvath & Kovacs 2002, Inoue et al 2002. They also possess phagocytotic activity (Horvath et al 1974, Ogawa et al 1997.…”

Section: Discussionmentioning

confidence: 99%

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Horiguchi¹,

Kikuchi²,

Kusumoto³

et al. 2009

Journal of Endocrinology

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Folliculo-stellate (FS) cells in the anterior pituitary gland appear to possess multifunctional properties. Recently, the development of transgenic rats (S100b-green fluorescent protein (GFP) rats) that express GFP specifically in FS cells in the anterior pituitary gland has allowed us to distinguish and observe living FS cells in other kinds of pituitary cells. We used S100b-GFP rats to investigate the topographic affinity of FS cells for other pituitary cells. We observed living FS cells in enzymatically dispersed anterior pituitary cells of S100b-GFP rats under a fluorescent microscope, and noted that FS cells markedly extended and contracted cytoplasmic processes and formed interconnections with neighboring FS cells. In addition, FS cells adhered to small clusters of GFPnegative cells, which were primarily hormone-producing cells, and these clusters further aggregated during the course of cytoplasmic contraction. In the presence of laminin, fibronectin, and varying types of collagen, FS cells showed marked changes in shape and specific proliferative activity; however, GFP-negative cells did not. On reverse transcription-PCR analysis and immunohistochemistry, FS cells were shown to express integrin subunits, which are the cell surface receptors for extracellular matrix (ECM). In the anterior pituitary gland, FS cells and the various types of hormoneproducing cells generate a unique topography in the presence of basement membrane components and interstitial collagens. The novel characteristics of FS cells observed in the present study suggest that in the anterior pituitary gland, FS cells play important roles in determining and/or maintaining local cellular arrangement in the presence of ECM components.

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Section: Discussionmentioning

confidence: 99%

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Horiguchi¹,

Kikuchi²,

Kusumoto³

et al. 2009

Journal of Endocrinology

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“…In the mammalian brain, pluripotent neural stem cells have been discovered that not only have a potentiality extending beyond the region of the brain from which they are derived, but also may not be restricted to the brain at all (31,32). This innovative concept of a putative common neuro/hematopoietic stem cell in the adult mammalian forebrain (32), together with our own observations of a population of BM-related cells in the pituitary interstitial cell compartment (6,67,68), prompts a revitalization of Yoshimura's concept of a pituitary cell renewal system (33,102).…”

Section: New Approaches For Old Questionsmentioning

confidence: 90%

“…One of the earliest ideas concerning the function of pituitary FS cells is that they represent a renewal or stem cell system in the anterior pituitary (33,102). This idea regained interest in view of the revised definition of organ typic stem cells, advanced by the experimental findings of a neural stem cell system in the adult mammalian brain, an organ long considered to be entirely postmitotic (31).…”

Section: New Approaches For Old Questionsmentioning

confidence: 99%

History and perspectives of pituitary folliculo-stellate cell research

Allaerts¹,

Vankelecom²

2005

eur j endocrinol

157

129

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Historically, the study of folliculo-stellate (FS) cells of the anterior pituitary dates back to the onset of electron microscopical observation of the pituitary gland. The morphological and electrophysiological characteristics, topographical distribution and contribution to intercellular junctions of these FS cells have been instrumental to the understanding of their putative function. Moreover, many studies have documented the role of FS cells as a source of newly discovered peptides, growth factors and cytokines. Quantitative immunohistochemical observation of FS cells in situ and functional in vitro studies, using either cultured FS cells or cells from an immortalized FS cell line, forwarded the notion of immunophenotypical and functional heterogeneity of the FS cell group. Double immunolabeling with a classical FS cell marker (S-100 protein) and with major histocompatibility complex class II markers characteristic for dendritic cells (DC) have shown a considerable overlap of FS cells with DC. The latter cells are immunocompetent cells belonging to the mononuclear phagocyte system. In this review, the FS cell heterogeneity is discussed with respect to the question of their embryological origin and developmental fate and with respect to the physiological relevance of functionally heterogeneous subpopulations. Recent findings of a myeloid origin of part of the interstitial cells of the anterior pituitary are confronted by other developmental paradigms of pituitary cell differentiation. The possibility that FS cells represent an adult stem cell population of the pituitary is critically examined. Also the physiological role of FS cells in the interferon-g-and nitric oxide-mediated effects on pituitary hormone secretion is discussed. New approaches for the study of this enigmatic cell group using immortalized cell lines and new markers for an hitherto unrecognized pituitary cell population, the so-called 'side population', are evaluated.

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“…It is tenable to assume that the corticotroph may emerge from the F-C cell. Hypergranulation takes place in the fully differentiated4th type in which the secretory granules150-250nm in diameter are accumulated in Gabe (1972), in hedgehogs by Girod et al(1975), and in rats by Yoshimura et al(1977a). Some investigators believed the F cells to appertaine to the glandular cells (Amat and Boys, 1973;Horvath et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Various types of the pituitary folliculo-stellate cells involving the Siperstein's corticotroph in the normal rats.

et al. 1980

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Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special reference to an interpretation of renewal cell system.

Cited by 101 publications

References 6 publications

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

History and perspectives of pituitary folliculo-stellate cell research

Various types of the pituitary folliculo-stellate cells involving the Siperstein's corticotroph in the normal rats.

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