Development and evaluation of a spray applicator for platelet-rich plasma

Düregger, Katharina; Gäble, Alexander; Eblenkamp, Markus

doi:10.1016/j.colsurfb.2018.07.018

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Hard and soft tissue regeneration is mediated by a wide range of signaling events, which are regulated by numerous cytokines. Altough the origin of these molecules is not well-known, platelets have been found to be a key autologous source of growth factors [ 1 , 2 ]. Upon activation platelets secrete active proteins including platelet-derived growth factor (PDGF), transforming growth factor (TGF β), and insulin-like growth factor (IGF-I) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

Kardos

Hornyák

Simon

et al. 2018

IJMS

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Platelet-rich fibrin (PRF) membrane is a three-dimensional biodegradable biopolymer, which consists of platelet derived growth factors enhancing cell adhesion and proliferation. It is widely used in soft and hard tissue regeneration, however, there are unresolved problems with its clinical application. Its preparation needs open handling of the membranes, it degrades easily, and it has a low tensile strength which does not hold a suture blocking wider clinical applications of PRF. Our aim was to produce a sterile, suturable, reproducible PRF membrane suitable for surgical intervention. We compared the biological and mechanical properties of PRF membranes created by the classical glass-tube and those that were created in a single-syringe closed system (hypACT Inject), which allowed aseptic preparation. HypACT Inject device produces a PRF membrane with better handling characteristics without compromising biological properties. Freeze-thawing resulted in significantly higher tensile strength and higher cell adhesion at a lower degradation rate of the membranes. Mesenchymal stem cells seeded onto PRF membranes readily proliferated on the surface of fresh, but even better on freeze/thawed or freeze-dried membranes. These data show that PRF membranes can be made sterile, more uniform and significantly stronger which makes it possible to use them as suturable surgical membranes.

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Section: Introductionmentioning

confidence: 99%

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

Kardos

Hornyák

Simon

et al. 2018

IJMS

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“…The term ''PRP'' was coined by Marx in a maxillofacial surgery re-construction study in which platelet-rich products were applied to bone grafts. 33 The inchoate definition of PRP was a platelet solution obtained from autologous plasma with the platelet concentration above baseline. 34 However, researchers subsequently proposed other definitions.…”

Section: Definition Classification and Preparation Of Prpmentioning

confidence: 99%

Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries

Fang

Wang

Jiang

et al. 2020

Tissue Engineering Part B: Reviews

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Platelet-rich plasma (PRP) is an autologous platelet concentrate prepared from the whole blood that is activated to release growth factors (GFs) and cytokines and has been shown to have the potential capacity to reduce inflammation and improve tissue anabolism for regeneration. The use of PRP provides a potential for repair due to its abundant GFs and cytokines, which are key in initiating and modulating regenerative microenvironments for soft and hard tissues. Among outpatients, orthopedic injuries are common and include bone defects, ligament injury, enthesopathy, musculoskeletal injury, peripheral nerve injury, chronic nonhealing wounds, articular cartilage lesions, and osteoarthritis, which are caused by trauma, sport-related or other types of trauma, or tumor resection. Surgical intervention is often required to treat these injuries. However, for numerous reasons regarding limited regeneration capacity and insufficient blood supply of the defect region, these treatments commonly result in unsatisfactory outcomes, and follow-up treatment is challenging. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries.

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“…Furthermore, they are minimally invasive and cause less pain, with greater patient compliance. Several approaches using sprays have been used, from the administration of drugs [6][7][8] and topical therapy [9] to more advanced treatments, such as cell therapy [10]. Recently published review articles have highlighted specially the application of hemoglobin sprays [11,12], sprayable hydrogels [13,14], and mostly cell sprays [15,16].…”

Section: Introductionmentioning

confidence: 99%

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

Nozaki

Lima

Moraes

2022

Biomedical Materials & Devices

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The skin, as the body's main protection barrier from the environment, has an intrinsic self-repairable nature. However, proper wound healing only occurs under appropriate conditions. Skin wounds represent an economic burden on healthcare systems worldwide. Recent research has focused on developing new therapies, especially for chronic wounds. Among them, sprayapplied therapies have emerged as a promising strategy for allowing deeper penetration of the products, better conformability, easiness of application, lower discomfort for the patient, and lower risk of contamination during application. Specifically, sprayable wound dressings have been getting attention for enabling the treatment of severe cases or hard-to-heal wounds by incorporating different bioactive agents. Organic and inorganic compounds, natural extracts, signaling compounds, and live human cells have been investigated. In this context, this review summarizes the main findings of recently developed spray-applied bioactive wound dressings.

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Development and evaluation of a spray applicator for platelet-rich plasma

Cited by 8 publications

References 27 publications

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

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