Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy

Pamlényi, Krisztián; Kristó, Katalin; Sovány, Tamás; Regdon, Géza

doi:10.1016/j.heliyon.2022.e10364

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…This was expected, as with the addition of AA to the formulations there was an increase in the amount of total solids, increasing the thickness of the films. F3 and F2 differed significantly from the other formulations, similar results were observed by Pamlényi et al (2022).…”

Section: Mechanical Characterisation and Barrier Properties Of Filmssupporting

confidence: 83%

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Orally disintegrating films based on sodium alginate as a carrier vehicle for vitamin C

Palezi,

Fernandes,

Barbosa

et al. 2023

Int J of Food Sci Tech

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SummaryOrally disintegrating films (ODFs) have been studied for their innovative way of delivering active compounds into the oral cavity. The study aimed to develop and evaluate ODFs using sodium alginate and different concentrations of vitamin C. Four formulations were evaluated for barrier, mechanical, thermal, microstructural properties, surface pH, disintegration time and concentration of vitamins. The ODFs produced showed high solubility, pH close to oral and disintegration time ranging from 24.66 s for the control formulation to 56.28 s for the 1% ascorbic acid formulation. The release of vitamin C occurred after 1 min of reaction for all formulations with the lowest concentration (0.25%) releasing a volume of 80.46 mg g−1. Thermal analyses demonstrated the presence of sodium alginate and vitamin C, and an interaction between them, confirmed by FTIR spectra. This interaction was interesting for ODFs since it can affect the properties and release of the active compound from the polymeric matrix. The results positively demonstrated that sodium alginate can be a promising polymer in the production of ODFs and for use in the delivery of vitamin C.

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Section: Mechanical Characterisation and Barrier Properties Of Filmssupporting

confidence: 83%

“…F3 and F2 differed significantly from the other formulations, similar results were observed by Pamlényi et al . (2022).…”

Section: Resultsmentioning

confidence: 99%

Orally disintegrating films based on sodium alginate as a carrier vehicle for vitamin C

Palezi,

Fernandes,

Barbosa

et al. 2023

Int J of Food Sci Tech

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“…The ideal films for buccal administration are strong, flexible films that are not susceptible to tearing or cracking during packaging or application of the drug formulation. More precisely, they should be characterized by a high folding endurance, E%, and low values of TS and E. In fact, hard and brittle films are characterized by higher values of E and TS, but elastic films possess higher E% values [3,17,28]. All prepared formulations were subjected to folding endurance evaluation.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Mucoadhesive Alginate/Pectin Films Crosslinked by Calcium Carbonate as Carriers of a Model Antifungal Drug—Posaconazole

Szekalska,

Czajkowska-Kośnik,

Maciejewski

et al. 2023

Pharmaceutics

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The mucosal membrane of the oral cavity, due to its unique structure and availability, constitutes an appropriate site for the delivery of drugs, both with local and systemic effects. Mucoadhesive buccal films are drug dosage forms that due to their convenience of application, flexibility and size, are characterized by patients’ compliance. Sodium alginate and pectin are natural polymers from the polysaccharides group, with mucoadhesive properties, that are widely applied to obtain buccal films. However, their hydrophilic nature and poor water resistance limit their application in sustained drug release formulations. Hence, the aim of this investigation was to design alginate/pectin buccal films by a one-step crosslinking technique—with the application of calcium carbonate. This technique was applied to prepare crosslinked alginate and alginate/pectin mucoadhesive films with a model antifungal drug—posaconazole. The obtained formulations were evaluated for the impact of crosslinking and pectin’s presence on their pharmaceutical, mucoadhesive, mechanical and physicochemical properties. Additionally, the antifungal activity of the prepared films against Candida spp. was evaluated. It was shown that pectin’s presence in the formulations improved flexibility, mucoadhesion and antifungal activity. The crosslinking process reduced mucoadhesiveness and antifungal activity but significantly enhanced the mechanical properties and stability and enabled prolonged drug release.

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“…The Franz diffusion cell was utilized (constant at 37 degrees Celsius) with pH 6.8 phosphate buffer for 6 h. The samples were spectrophotometrically inspected at 239 nanometers. 11 Moisture uptake studies (or) swelling index: This is analysed as weight and swelling area growth. Weight increases due to swelling: A film of 10 mm size of individual batch is weighed on pre-weighed glass cover.It is set in a pH 6.8(10 ml) buffer containing petri dish.…”

Section: Introductionmentioning

confidence: 99%

Formulation and In-Vitro evaluation of Nortriptyline Hydrochloride mucoadhesive buccal films

Ilyas,

Fatima,

Shahidulla

2023

J. Drug Delivery Ther.

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This contemporaneous research was aimed to formulate buccal mucoadhesive DDS to enhance bioavailability and avoid pre systemic metabolism. The mucoadhesive film was fabricated by solvent casting method with base polymer chitosan and a combination of hydrophilic polymer like PVP or Gelatin. The films were then evaluated. All the formulations were found to have optimum strength to withstand folding endurance. The films' consistent size, thickness, and weight variation were discovered. The drug content uniformity of films was exceptionally well. Given that the film's surface pH falls between 6.6 and 6.7, buccal administration is appropriate for it. The pH near to the neutral region decreases the chances of mucosal irritation. The invitro adhesion ability of the formulations were affected by the composition of chitosan and PVP or Gelatin. The lower and higher concentration of chitosan was not sufficient for invitro adhesion of films. The formulation having chitosan and hydrophilic polymers in the ratio 1:1.5 showed strong invitro adhesion. The invitro bioadhesion time of the formulations containing chitosan and gelatin or PVP was less due to poor ionization of gelatin. On increasing the concentration of hydrophilic polymers, the invitro bioadhesion time increased. The highest concentration of the polymers decreased the adhesion time. The formulation NF5 with chitosan and gelatin within the proportion of 1:1.5 exhibited drug release of 98.1% at 6 hours. The sole purpose of this work is to adhere the buccal film with the mucosa, hence formulation NF5 was selected as best formulation. Thus, current investigation's goal to develop a buccal mucoadhesive drug delivery was fulfilled. Keywords: Buccal film, Nortriptyline HCl, depression, in vitro studies, mucoadhesive

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Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy

Cited by 11 publications

References 37 publications

Orally disintegrating films based on sodium alginate as a carrier vehicle for vitamin C

Orally disintegrating films based on sodium alginate as a carrier vehicle for vitamin C

Mucoadhesive Alginate/Pectin Films Crosslinked by Calcium Carbonate as Carriers of a Model Antifungal Drug—Posaconazole

Formulation and In-Vitro evaluation of Nortriptyline Hydrochloride mucoadhesive buccal films

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