Development and Evaluation of Biocompatible Topical Petrolatum-liquid Crystal Formulations with Enhanced Skin Permeation Properties

Abstract

IntroductionThe first line of defence is the skin, preventing foreign things from entering the human body system and preventing water loss from the body via evaporation 1,2) . The stratum corneum is a complex outermost layer of the skin that acts as the initial physical barrier to any external elements, including medicines, entering the body, which also makes an obstacle in the drug penetration into the body 2) . However, owing to its simple and convenient accessibility, the skin remains an appealing route of drug administration,

Evaluation of the Skin Permeation-Enhancing Abilities of Newly Developed Water-Soluble Self-Assembled Liquid Crystal Formulations Based on Hexosomes

“…The PEG LC formulations' safety on HaCaT cells was also proven at a higher dose, 1 mg/mL, where cell survival was >90%. Prior studies using human keratinocytes to examine the safety of various recently manufactured formulations [35,36] support our findings.…”

Characterizations of Liquid Crystals as A Transdermal Drug Delivery System

“…In addition, the impact of the Petrolatum-LC formulations on DNA damage was also evaluated. There was no apparent DNA damage in the HaCaT cells treated with Petrolatum-LC formulations up to 1 mg/mL [25].…”

“…These formulations were designed based on different ratios of the active ingredient in distilled water (drug solution) and LC-forming lipids. GMO was melted at 70°C before use, but MGE was dispersed with drugs solution without preheating [24][25][26].…”

Functional nano-systems for transdermal drug delivery and skin therapy

“…In an in vitro skin permeation study, the mixture formulations dramatically enhanced drug skin concentrations compared to the white petrolatum. 121 These results showed that ISAsomes will bring about enormous opportunities in transdermal drug delivery.…”