Development and Evaluation of Drug Loaded Regenerated Bacterial Cellulose-Based Matrices as a Potential Dosage Form

Abstract

Bacterial cellulose (BC) is a highly pure form of cellulose and possesses superior physico-mechanical properties with wide range of applications. These properties of BC can further be improved by various modifications, including its regeneration from the BC solution. In the current research work, regenerated BC (R-BC) matrices were prepared using N-methyl-morpholine-oxide (NMMO; 50% w/w solution in water) and loaded with model drugs, i.e., famotidine or tizanidine. The characterization of drug loaded regenerated BC (R-BC-drug) matrices was carried out using Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD) analysis, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA), which revealed the stability of matrices and successful drug loading. Results of dissolution studies showed immediate (i.e., >90%) drug release in 30 min. The drugs release data was found to best fit into first order kinetics model having R2 values >0.99 for all the formulations. These results indicated that regenerated BC-based matrices had the ability to be used for delivery of orally administered drugs.

Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems

“…This hybrid dielectric was created from tetrakis-dimethyl-aminozirconium and 2-hydroxyethyl methacrylate-a high-k inorganic material and a soft organic material, respectively. The resulting film demonstrated a high dielectric constant, low leakage current density, and high breakdown field, indicating its suitability for advanced flexible electronic applications [11,12].…”

Purification and Immobilization of Superoxide Dismutase Obtained from Saccharomyces cerevisiae TBRC657 on Bacterial Cellulose and its Protective Effect against Oxidative Damage in Fibroblasts

“…The obtained results revealed that immobilization of SOD on BC enhanced its stability more than 40% after incubating at higher pH levels and temperatures compared to the free SOD, which typically degraded under those conditions. Therefore, the immobilization process using BC or other substances holds the potential to improve the stability of bioactive compounds under various conditions, which is a critical factor for the labile compounds [39,41].…”

Recent Trends in Assessment of Cellulose Derivatives in Designing Novel and Nanoparticulate-Based Drug Delivery Systems for Improvement of Oral Health

“…NMMO treated BC is called regenerated bacterial cellulose (R-BC). R-BC has been widely implemented in drug delivery e.g it has been used for H2-blochers drugs (famotidine) and muscle relaxant (tizanidine) [ 80 ].…”