Development and Evaluation of in Situ Gelling Gastroretentive Formulations of Meloxicam

Abstract

Objective: The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is an NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic and antipyretic effects. Methods: Four polymer based floating in situ gelling systems of Meloxicam were prepared by dissolving varying concentrations of different ingredients including sodium alginate, HPMC K100M, calcium carbonate, sodium citrate. The prepared gels were characterized for solution viscosity, pH, gelling capacity, floating lag time, floating duration and in-vitro release study. Results: The formulations possessed satisfactory pH value ranging from 7.25±0.09 to 8.12±0.49. All the formulations showed instant gelation maintaining integrity for at least 12 h. Maximum drug release was shown by formulations of batch G1 (94.38%). Conclusion: The study demonstrated that a stomach specific in-situ gel of Meloxicam could be prepared using the floating mechanism to increase the residence time of the drug in the stomach and improve bioavailability and thus improve patient compliance.

Development and Characterization of In Situ Gel Containing Leflunomide as a Gastro-retentive Drug Delivery

“…All the prepared formulations had off-white appearance and showed no lumps in the preparation as shown in figure (3). The formulations did not produce any gelation at room temperature.…”

“…Batches "C" were prepared to study the effect of calcium carbonate concentration on in-vitro release, the floating lag time, gel strength, pH, viscosity and the other physical properties of the in-situ gel. The concentration of calcium carbonate was varied from 0.25, 0.5, 0.75, 1.0 and 1.5% in batches of C1 to C5, respectively as shown in table (3). Weight of sodium citrate (0.25% w/v) was kept constant in all batches of "S" and "C".…”

“…The pH values were determined for each in situ gel formulations and the results are shown in table (3). The formulations possessed satisfactory pH value ranging from 9.01 to 9.3 which is suitable to maintain the formulations in a liquid state.…”

“…The in-situ gel dosage form is a liquid before administration but converts into a gel that floats on gastric contents as it comes in contact with it. It consists of a solution of low viscosity that on coming in contact with the gastric fluids, undergoes change in polymeric conformation, viscous gel having density lower than the gastric fluids thus floats on the surface of it 3 .…”

Formulation and Evaluation of Ibuprofen Gastro Retentive Floating Tablets

“…The drum was rotated at 25 rpm for 4 minutes after which the tablets were removed. Any loose dust was removed from the tablets as before and the tablets were weighed again 24,25 . The percentage friability was then calculated by…”