Development and evaluation of liposomal formulation containing nimodipine on anxiolytic activity in mice

Moreno, Lina Clara Gayoso e Almendra Ibiapina; Oliveira, Giselle Zayra da Silva; Cavalcanti, Isabella Macário Ferro; Santos-Magalhães, Nereide Stela; Rolim, Hercí­lia Maria Lins; Freitas, Rivelilson Mendes de

doi:10.1016/j.pbb.2013.10.023

Cited by 21 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Benzodiazepines have been the mainstay of treatment for epilepsy and anxiety disorders. However, they are associated with serious side effects such as amnesia, tolerance, muscle weakness, changes in body weight, loss of sexual drive and physical dependence which lead patients to seek alternative therapies (Moreno et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn)

Irshad

Khan

Mohammad

et al. 2015

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn)

Irshad

Khan

Mohammad

et al. 2015

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…Anxiety, indicative of a primary psychiatric condition is characterized by sense of unease and trepidation and generally excessive and uncontrollable worry about several factors [287,288]. Anxiolytic agents continue to be the mainstay for the treatment of anxiety.…”

Section: Anxiolytic Activitymentioning

confidence: 99%

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

Shaquiquzzaman

Verma

Marella

et al. 2015

European Journal of Medicinal Chemistry

198

View full text Add to dashboard Cite

“…Performance impairment of numerous tasks are caused by anxiety disarrays and high rates of medically untold etiology are connected with enhancing the utilization of healthcare, that are sharply and independently attached with severe medical distemper, low levels of lifestyle, and inabilities [ 6 ]. Furthermore, uncontrolled and exorbitant worry has a considerable number of factors that varies from person to person and these troubles are experienced as getting easily fatigued, muscle tension, and sleep disturbance [ 8 ]. On the other hand, sleep disturbance causes insomnia, and that is the reason anxiety turns a human to an insomniac.…”

Section: Introductionmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

View full text Add to dashboard Cite

Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

show abstract

Development and evaluation of liposomal formulation containing nimodipine on anxiolytic activity in mice

Cited by 21 publications

References 32 publications

GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn)

GABAA receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn)

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

Contact Info

Product

Resources

About