Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin

Lacerda, Loreana; Parize, Alexandre Luís; Fávere, Valfredo T.; Laranjeira, Mauro C. M.; Stulzer, Hellen Karine

doi:10.1016/j.msec.2014.01.054

Cited by 91 publications

(45 citation statements)

References 48 publications

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“…Most of them use calcium as the cross linking metal. But calcium-alginate complexes were reported to show some disadvantages such as sensitivity towards the physiological environment and rapid release of encapsulated drug 7 . It was found that zinc ions possess a superior binding capacity towards alginate than calcium and which are more resistant to hydration 8 .…”

Section: Introductionmentioning

confidence: 99%

Zinc Alginate Beads for the Controlled Release of Rifampicin

Deepathomas¹,

Latha²,

KurienThomas³

2018

Orient. J. Chem

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The present study describes the preparation of a carrier system based on zinc-alginate beads and to evaluate its potential for the controlled release of rifampicin, the poorly water soluble drug using ionic gelation technique. The surface topology of the developed beads were analyzed by Scanning Electron Microscopy and the crosslinking process was investigated by Fourier Transform. Infrared spectroscopy. The pH dependent swelling properties of the beads were analyzed. Drug entrapment efficiency and in vitro drug release studies were also investigated. The in vitro cytotoxicity and antibacterial activity were evaluated. Results indicated that the entrapment efficiency improves as the amount of polymer incresed. The developed beads showed a pH dependent swelling behaviour. The sustained release of drug was more prominent in pH 7.4 than 1.2. The MTT assay results proved the cell biocompatibility of the developed beads. The beads showed good antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Zinc Alginate Beads for the Controlled Release of Rifampicin

Deepathomas¹,

Latha²,

KurienThomas³

2018

Orient. J. Chem

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“…Cefaclor release from alginatechitosan microparticles in simulated gastric fl uid is intensifying with increasing of alginate concentration up to 7% w/v (chitosan concentration -0.5% w/v) [53]. Similar release profi le was observed for systems containing antituberculosis drug rifampicin and for which obtaining was used 1% alginate and 1.5% chitosan [55]. Alginate-chitosan beads with metronidazole were obtained; due to high contents of chitosan (5% w/v) fl oat on gastric juice and consequently are retained in the stomach where they gradually release antibiotic compound [51].…”

Section: Microparticlesmentioning

confidence: 73%

Recent Trends in Alginate, Chitosan and Alginate-Chitosan Antimicrobial Systems

Albert¹

2016

ChemJMold

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Abstract. Natural polysaccharides alginate and chitosan have been used extensively, separately or in mixtures (systems), in manufacturing of pharmaceutical products (antimicrobial) and not only. Alginates usually serve as basis for antimicrobial systems, while chitosan, in certain proportions, enhances their physicochemical and antimicrobial properties. Focusing on the recent literature (mostly since 2000), this review outlines the main synthetic approaches for the preparation of systems based on both polymers as well as identify potential areas of their application as antimicrobial agents. Various techniques used for systems preparation like microparticles, fi lms, fi bers, nanoparticles, sponges, applications and usefulness of these systems as carriers of antimicrobial compounds will also be discussed.

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“…This can be modulated by the morphological and physicochemical characteristics of microparticles, as size and porosity of the particle loaded with the immunologic agent 24,25 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

IJPSR

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ABSTRACT:Controlled release systems for protein and peptide vaccines based polymers have been considered for many applications in medical therapies. Chitosan is non-toxic and easily absorbed biopolymers and is often used in many researches to sustained release drugs and proteic vaccines. This study investigates the kinetics of release in vitro of bovine serum albumin (BSA) from chitosan microparticles and the effect of the preparation process of the microparticles in the release rate. Chitosan microparticles were design by a coacervation / precipitation method under different time's sonication and different protein / chitosan ratio were used (0, 5 to 2 g. g -1 ). To the in vitro study of the protein release, the microparticles were resuspended in PBS pH 7.4 at 37 °C under stirring and the samples in different intervals were aliquoted to dosage of BSA release. The morphology of the chitosan microparticles was examined with Electron Microscopy, which showed particle size between 10 -30 µm and porous structures. Studies were conducted to investigate the BSA stability during the process of BSA loaded, no BSA degradation, through electrophoresis in polyacrylamide gel, were observed the microparticles prepared with 20 minutes of sonication had a higher speed BSA release, in relation to the other sonication times, being 0.86 µg/mL -1 / min -1 , with BSA/chitosan ratio of 1, 5g. g -1 . These data showed that the preparation process is an important factor in controlling release of protein from chitosan microparticles, and this can become a potential for carrier vaccines in mucosal delivery systems.

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Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin

Cited by 91 publications

References 48 publications

Zinc Alginate Beads for the Controlled Release of Rifampicin

Zinc Alginate Beads for the Controlled Release of Rifampicin

Recent Trends in Alginate, Chitosan and Alginate-Chitosan Antimicrobial Systems

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