Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

Shetty, Pallavi K.; Venuvanka, Venkatesh; Jagani, Hitesh; Honnappa, Chethan Gejjalagere; Ligade, Virendra S; Musmade, Prashant B; Nayak, Usha Yogendra; Reddy, M. Sreenivasa; Kalthur, Guruprasad; Udupa, N.; Chamallamudi, Mallikarjuna Rao; Mutalik, Srinivas

doi:10.2147/ijn.s90964

Cited by 41 publications

(32 citation statements)

References 42 publications

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“…These free radicals threaten the integrity of skin as they do to other tissues [85, 86], but the skin is at risk because its exposition to oxygen from the inside at levels provided by the blood and from the outside at higher levels provided by the air, and the continuous exposition to light [34], which generates hydroxyl radicals through breakage of hydrogen peroxide (H 2 O 2 + UV radiation → 2 HO•). Free radicals can also be formed by the presence of xenobiotics that can contain ions Fe(II) or Cu(I) that act as a catalyst of hydrogen peroxide decomposition (H 2 O 2 + Fe(II)/Cu(I) → HO• + HO - + Fe(III)/Cu(II)).…”

Section: Resultsmentioning

confidence: 99%

“…Several beneficial effects have been described, including anticancer [28], anti-inflammatory [29] and cardiovascular protective effects [30–32]. Moreover, morin (MOR) has shown interesting protective effects against UV-B radiation [33, 34], therefore its incorporation in topical formulation can be beneficial for skin health. However, its technological application (pharmaceutical and cosmetic formulations) is limited because this polyphenolic compound is sensitive to several environmental factors such as light, oxygen and pH among others [35].…”

Section: Introductionmentioning

confidence: 99%

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Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

et al. 2016

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Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

et al. 2016

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“…Physical UV absorbers like titanium dioxide and zinc oxide have been considered as highly protective agents against UVR. ZnO and TiO2 combinations are particularly valuable because of their ability to filter both UVA and UVB radiations, providing broader UVR protection than that observed with individual component [95]. They are used in sunscreens as nanoparticles, which denotes a size <100 nm.…”

Section: Classification Of Sunscreensmentioning

confidence: 99%

“…Most sunscreens combine chemical UV absorbing sunscreens and physical inorganic sunscreens, which reflect UV, to provide broad-spectrum protection. The correct use of sunscreens should be combined with the avoidance of midday sun and the wearing of protective clothing and glasses, as part of an overall sun protection regimen [94,95]. Unfortunately, inaccurate information is currently roaming the media and the Internet regarding the safety, toxicity, and acute side effects of the active ingredients currently used in sunscreens, therefore discouraging people from using sunscreens [92].…”

Section: Classification Of Sunscreensmentioning

confidence: 99%

Sunscreen and Suntan Preparations

2019

ARC Journal of Pharmaceutical Sciences

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BACKGROUND Ra (Re) was the primary name of the sun god of Ancient Egypt. According to Osiris myth, Nut, the mother of Osiris swallowed the setting sun (Ra) each evening and gave birth to him each morning. The Ancient Egyptians were well aware of the dangers of the sun. Their lands were scorched with heat. Women protected their skin, preferring light skin to dark in their cultural hierarchy of beauty. Recent discoveries written on papyri and the walls of several tombs unearthed ingredients and formulations in use in Ancient Egypt specifically addressing issues of sun damage to the hair and skin. Also, a brief historical review manifests the following interesting things indeed: ▪ Jasmin was used to heal the sun-damaged skin. Recent evidence reveals that Jasmin aids in DNA repair at the cellular level. ▪ Aloe was used to heal sun-damaged skin. ▪ Olive oil was used as a hydrating oil for both skin and hair damaged by overexposure to the sunlight. ▪ Almond oil was applied before and after sun exposure to hydrate the sun-damaged skin, improving elasticity and texture. ▪ Rice bran extracts were used in sunscreen preparations. Today, gamma oryzanol extracted from rice bran has UV absorbing properties. ▪ kohl (to darken eyes in order to combat sunlight impairment to the retina in the glare of the desert sun), red ochre (to redden and impart a rosy glow in women's makeup mimicking the effect of the sun on the skin), and henna oil (to dye the lips and nails, darken the color of the hair and skin, and protect light skin from the sun). Today, henna is one of the most widely used natural sunscreen with both UVA and UVB protection.

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“…It is a pentahydroxyflavone and a 7-hydroxyflavonol [162]. ZnO and TiO2 combinations are particularly valuable because of their ability to filter both UVA and UVB radiations, providing broader UVR protection than that observed with individual component [95].…”

Section: Exhibit 9 Aqueous Non-aqueous and Clear Sunscreen Lotion Fmentioning

confidence: 99%

An Extensive Review of Sunscreen and Suntan Preparations

Mohiuddin¹

2019

Preprint

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The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photo protection. The need for broad-spectrum protection from both UVA and UVB rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photo damaging effects caused by ultraviolet radiation has increased the use of sun screening agents, which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the FDA is required to define sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the Advance Notice of Proposed Rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-OTC monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the SPF number in a product is governed by simple chemical principles.

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Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

Cited by 41 publications

References 42 publications

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

Sunscreen and Suntan Preparations

An Extensive Review of Sunscreen and Suntan Preparations

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