Development and evaluation of the tablets coated with the novel formulation termed thin-layer sugarless coated tablets

Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

“…On the other hand, sugar-coated tablets have problems of remarkable size increase, higher calorie content, and relatively high moisture content. To improve these drawbacks, Ohmori et al reported the development of a thin-layer sugarless coating with erythritol by a continuous spray method [8]. This thin-layer sugarless coating enables the masking of drug odors and increases the stability because of its low hygroscopicity [8].…”

“…To improve these drawbacks, Ohmori et al reported the development of a thin-layer sugarless coating with erythritol by a continuous spray method [8]. This thin-layer sugarless coating enables the masking of drug odors and increases the stability because of its low hygroscopicity [8]. The preparation of a thin-layer sugarless coating involves four steps: (i) under coating, (ii) build-up coating, (iii) syrup coating, and (iv) polishing, a tedious method.…”

“…Mannitol has one of the lowest hygroscopicities compared with other sugarless compounds [8]. Although it is widely used as an excipient in pharmaceutical products [15], it is not utilized for the pharmaceutical coating of tablets.…”

Improving Stability of Vitamin B5 Through Double Salt Formation

“…For example, using crystalline calcium pantothenate, or mixing calcium pantothenate with magnesium carbonate, calcium lactate, or calcium carbonate . CP can be more stable in tablets by adding calcium pantothenate to the coating layer due to the less contact among CP and acidic substances …”

“…20 CP can be more stable in tablets by adding calcium pantothenate to the coating layer due to the less contact among CP and acidic substances. 21 The major degradation pathway of CP is presented in Scheme 1. 22 The amide bond is broken to form β-alanine and pantoic acid by hydrolysis.…”