Ultrasonic welding is increasingly used in industry. In this paper, the influence of ultrasonic welding parameters (USW) on the joint strength and quality was analysed. The properties of the USW joints depend on many factors. The work focuses on the influence of the technological parameters and the surface properties of welded EN Cu-ETP copper sheets with a thickness of 1 mm. The impact of the process parameters, such as welding time, pressure, vibration amplitude and the surface roughness on the lap shear strength and the metallographic weld properties was analysed. The welding energy for each variant was also determined. The research was conducted on the basis of a full factorial design of experiments. The optimal process parameters were determined to obtain high-quality joints in terms of strength and weld quality. Based on the presented experimental study, it was demonstrated that the ultrasonic vibration amplitude has the greatest impact on the joint strength. A surface preparation with acetone resulted in the highest tensile strength and welding energy and, making any additional surface treatment prior to welding unnecessary.