Development and evaluation of viscosity-enhanced nanocarrier (VEN) for oral insulin delivery

Boushra, M.F.; Tous, S. Shawky; Fetih, Gihan; Korzekwa, Kenneth R.; Lebo, David B.; Xue, Hui; Wong, Ho Lun

doi:10.1016/j.ijpharm.2016.07.016

Cited by 29 publications

(16 citation statements)

References 41 publications

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“…(b) A strategy for loading hydrophilic drugs in the core of solid nanoparticles (blue color) by generation of a hydrophilic viscose phase in the core. Reprinted from [101], Copyright (2016), with permission from Elsevier. (c) A two-step preparation method for insulin-loaded core-shell nanoparticles composed of a modified chitosan core coated with thiolated hyaluronic acid through electrostatic [114].…”

Section: Polymeric Nano and Microparticlesmentioning

confidence: 99%

“…In this strategy, the core of orally administered SLNs consists of a solid lipid core and a hydrogen-bonded rich aqueous phase encapsulating insulin, which is either dispersed in the lipid phase or is formed like a central core in the lipid matrix ( Fig. 5 b) [ 101 ]. Although surface functionalization of SLNs with PEG enhances their hydrophilicity, a reduction in muco-adhesion of SLNs is also observed.…”

Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

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Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

169

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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Section: Polymeric Nano and Microparticlesmentioning

confidence: 99%

Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

169

View full text Add to dashboard Cite

show abstract

“…Hecq et al 102 dissolved Ins into the inner aqueous phase and then emulsified in an organic phase to prepare a bioadhesive cationic SLPs, which increased 2.5-fold the transshipment of capped Ins through co-cultured Caco-2/HT29 cells compared to free Ins. Boushra et al 103 adopted three different hydrophilic viscosity-enhancing agents (VAs): propylene glycol (PG), PEG 400 and PEG 600 within SLP cores to develop Ins-loaded NCs with enhanced viscosity. The highest EE was achieved by 70% ( w / w ) PG contained NCs (54.5%) compared to only 20.4% in unmodified SLN and achieved good hypoglycemic effect with a relative bioavailability of 5.1% following oral administration.…”

Section: Lipid-based Particlesmentioning

confidence: 99%

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Han

Gao

Chen

et al. 2019

Acta Pharmaceutica Sinica B

113

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In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by harsh gastrointestinal environment and poorly penetrating epithelial barriers often results in low bioavailability (less than 1%–2%). Therefore, delivery systems that are rationally designed to overcome these challenges in gastrointestinal tract and ameliorate the oral bioavailability of therapeutic peptides/proteins are seriously promising. In this review, we summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins.

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“…The burgeoning field of biomedical engineering has rapidly morphed from basic research into translational medicine, with the application of engineering principles to cancer diagnostics, drug delivery, imaging, and infectious disease detection, to name a few applications (12–15). This field, together with genomic analysis, has ushered in personalized medicine in humans.…”

Section: Nanoengineeringmentioning

confidence: 99%

Veterinary Pathology – A Path Forward with New Directions and Opportunities

Stokol

2016

Front. Vet. Sci.

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Development and evaluation of viscosity-enhanced nanocarrier (VEN) for oral insulin delivery

Cited by 29 publications

References 41 publications

Micro and nanoscale technologies in oral drug delivery

Micro and nanoscale technologies in oral drug delivery

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Veterinary Pathology – A Path Forward with New Directions and Opportunities

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