The paper analyzes the stiffness of the Orthofix external fixation system at axial pressure load, applied to the lower leg in case of an unstable fracture. Based on the actual construction of the Orthofix fixator, its 3D model was formed, and then a structural analysis was performed in the CATIA V5 software system. The aim of this paper is to investigate the mechanical properties of Orthofix fixator. FEM analysis of the fixator revealed displacements at characteristic points of the structure and fractures. During the FEM analysis, it is possible to change the load values, all with the aim of obtaining the best possible information about the behavior of the fixator during installation and use by the patient. Based on the results obtained from the FEM analysis, it can be concluded that the Orthofix fixative shows very good stiffness, but also that it can be improved by using newer materials, such as composite or some alloys of titanium and aluminum.