Development and External Validation of a Nomogram Including Body Composition Parameters for Predicting Early Recurrence of Hepatocellular Carcinoma After Hepatectomy

Establishing and Externally Validating a Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score-Based Nomogram for Predicting Early Recurrence in BCLC Stage 0/A Hepatocellular Carcinoma Patients After Radical Liver Resection: A Multi-Center Study

“…Consistent with previous reports, 22,[27][28][29] the results of multivariate Cox regression analysis in this study showed that HBV DNA load ≥10,000 IU/mL, tumor size, Edmondson-Steiner grade (III-IV), satellite nodules, and MVI were independent risk factors for postoperative recurrence in patients with BCLC stage 0/A HCC. HBV DNA load reflects the level of viral replication, which is a key driver of liver injury and HCC development, and higher levels negatively impact the prognosis.…”

“…Currently, the commonly used staging systems like BCLC stage and Tumor-Node-Metastasis (TNM) staging system of the American Joint Committee on Cancer (AJCC) primarily consider factors such as tumor size, number, and MVI. 24,26 Because the postoperative recurrence of HCC is influenced by numerous factors, including nutritional and immune status, portal hypertension, HBV DNA load, Edmondson-Steiner grade, satellite nodules, etc; 18,[27][28][29][30] the ability to perform individualized assessments of patients using the common staging systems is limited. Previous prognostic models mainly focused on tumor-related variables and did not consider other conditions, such as the nutritional and immune status of the patients or liver cirrhosis.…”