Development and Homeostasis of the Skin Epidermis

Sotiropoulou, Panagiota A.; Blanpain, Cédric

doi:10.1101/cshperspect.a008383

Cited by 92 publications

(75 citation statements)

References 199 publications

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“…Epidermal homeostasis is maintained by a tightly regulated balance of renewal and differentiation processes [91]. This homeostatic balance is disturbed in chronic inflammatory diseases, such as psoriasis, leading to abnormal differentiation associated with a shortened cellular turnover time [92].…”

Section: Resultsmentioning

confidence: 99%

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease – a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.

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Section: Resultsmentioning

confidence: 99%

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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“…One candidate for a marker of mouse IFE stem cells is LGR-6 (Fig. 4) (Snippert et al 2010a;Sotiropoulou and Blanpain 2012;Page et al 2013).…”

Section: Stem Cells Of the Interfollicular Epidermismentioning

confidence: 99%

Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

Kretzschmar

Watt

2014

Cold Spring Harbor Perspectives in Medicine

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“…The skin epidermis is a stratified epithelium consisting of the interfollicular epidermis (IFE) and its appendages: the hair follicles (HFs) and the associated sebaceous glands (SGs) (Blanpain and Fuchs 2006;Sotiropoulou and Blanpain 2012). The homeostasis of these different epidermal compartments is ensured by different pools of resident stem cells (SCs), each of which is located in a different niche (Blanpain and Fuchs 2009).…”

mentioning

confidence: 99%

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

et al. 2012

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The accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process. Here, we performed conditional deletion of Brca1 during epidermal development and found that BRCA1 is specifically required for hair follicle (HF) formation and for development of adult HF stem cells (SCs). Mice deficient for Brca1 in the epidermis are hairless and display a reduced number of HFs that degenerate progressively. Surprisingly, the interfollicular epidermis and the sebaceous glands remain unaffected by Brca1 deletion. Interestingly, HF matrix transient amplifying progenitors present increased DNA damage, p53 stabilization, and caspase-dependent apoptosis compared with the interfollicular and sebaceous progenitors, leading to hyperproliferation, apoptosis, and subsequent depletion of the prospective adult HF SCs. Concomitant deletion of p53 and Brca1 rescues the defect of HF morphogenesis and loss of HF SCs. During adult homeostasis, BRCA1 is dispensable for quiescent bulge SCs, but upon their activation during HF regeneration, Brca1 deletion causes apoptosis and depletion of Brca1-deficient bulge SCs. Our data reveal a major difference in the requirement of BRCA1 between different types of epidermal SCs and progenitors and during the different activation stages of adult HF SCs.

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Development and Homeostasis of the Skin Epidermis

Cited by 92 publications

References 199 publications

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

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