Development and in vitro Evaluation of Voriconazole Nanoparticle Formulation for Mucosal Application

Rençber, Seda; Karavana, Sinem Yaprak

doi:10.4274/tjps.54265

Cited by 5 publications

(6 citation statements)

References 29 publications

(25 reference statements)

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“…The release was characterized by diffusion, and the method was considered promising for topical administration. The authors justify the result by the association of chitosan, which has mucoadhesive properties [ 229 ].…”

Section: Nanotechnology-based Voriconazole Delivery Systemsmentioning

confidence: 99%

“…The characteristic of allowing the incorporation of different molecules into the polymeric nanoparticle allows for an increase in the interaction of the nanostructured system with the target tissue [ 229 , 283 , 284 ]. This has been explored in the literature with chitosan, which is known to have a mucoadhesive property and allows the increase in the delivery of VCZ in the target tissue [ 218 , 221 , 230 , 247 ].…”

Section: Nanotechnology-based Voriconazole Delivery Systemsmentioning

confidence: 99%

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Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

et al. 2023

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Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant to fluconazole, and for infections caused by endemic mycoses, in addition to those that occur in the central nervous system. However, despite its broad activity, using voriconazole has limitations related to its non-linear pharmacokinetics, leading to supratherapeutic doses and increased toxicity according to individual polymorphisms during its metabolism. In this sense, nanotechnology-based drug delivery systems have successfully improved the physicochemical and biological aspects of different classes of drugs, including antifungals. In this review, we highlighted recent work that has applied nanotechnology to deliver voriconazole. These systems allowed increased permeation and deposition of voriconazole in target tissues from a controlled and sustained release in different routes of administration such as ocular, pulmonary, oral, topical, and parenteral. Thus, nanotechnology application aiming to delivery voriconazole becomes a more effective and safer therapeutic alternative in the treatment of fungal infections.

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Section: Nanotechnology-based Voriconazole Delivery Systemsmentioning

confidence: 99%

Section: Nanotechnology-based Voriconazole Delivery Systemsmentioning

confidence: 99%

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

et al. 2023

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“…Ketoprofen telah terbukti efektif mengobati nyeri sedang hingga berat, terutama pada individu yang pulih dari operasi. Dalam periode 24 jam, penggunaan ketoprofen menurunkan tingkat nyeri sedang (4,63) menjadi rasa tidak nyaman ringan (1,76) (Rencber et al, 2009).…”

Section: Hasil Dan Pembahasanunclassified

Gambaran Penggunaan Obat Antipendarahan dan Antinyeri pada Pasien Rawat Inap Kanker Serviks Di Rumah Sakit X Wilayah Kota Gorontalo Periode 2021-2022

Papeo,

Samatowa,

Silaka

et al. 2023

jmpi

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Kanker serviks atau kanker rahim merupakan keganasan dari leher rahim (serviks) yang dapat disebabkan karena adanya virus HPV (Human papiloma virus). Data dari World Health Organization (WHO) diketahui terdapat 493.243 jiwa pertahunpenderita kanker serviks baru dengan angka kematian sebanyak 273.505 jiwa pertahun. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran penggunaan obat antipendarahan dan antinyeri pada pasien kanker serviks di rumah sakit “X”. Penelitian ini menggunakan metode deskriptif retrospektif dengan populasi 8 pasien yang terdiagnosa kanker serviks di rumah sakit “X” di wilayah Kota Gorontalo periode 2021-2022. Berdasarkan hasil penelitian terdapat pasien kanker serviks yang menjalani rawat inap di rumah sakit “X” wilayah kota Gorontalo diketahui bahwa antinyeri yang paling banyak digunakan yaitu asam mefenamat dengan persentase 6,67% dengan dosis 500 mg, Fibrinolitik yang paling banyak digunakan di rumah sakit “X” yaitu asam tranexamat dengan dosis 500 mg.

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“…Mucoadhesion of BR Ext-loaded NGs was determined by the method proposed by Rençber et al (2018) [26]. To this end, NG suspension turbidity was compared with single mucin dispersion at 650 nm using a UV/Vis double beam spectrophotometer.…”

Section: Mucoadhesive Evaluationmentioning

confidence: 99%

Chitosan-Based Nanogels Designed for Betanin-Rich Beetroot Extract Transport: Physicochemical and Biological Aspects

Silva Nieto,

Samaniego López,

Moretton

et al. 2023

Polymers

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Nanotechnology has emerged as a possible solution to improve phytochemicals’ limitations. The objective of the present study was to encapsulate beetroot extract (BR Ext) within a chitosan (CS)-based nanogel (NG) designed via ionic crosslinking with tripolyphosphate (TPP) for betanin (Bet) delivery, mainly in the ophthalmic environment. BR Ext is rich in betanin (Bet) according to thin layer chromatography (TLC), UV-visible spectroscopy, and HPLC analysis. NG presented a monodisperse profile with a size of 166 ± 6 nm and low polydispersity (0.30 ± 0.03). ζ potential (ζ-Pot) of +28 ± 1 is indicative of a colloidally stable system. BR Ext encapsulation efficiency (EE) was 45 ± 3%. TEM, with the respective 3D-surface plots and AFM, showed spherical–elliptical-shaped NG. The BR Ext release profile was biphasic with a burst release followed by slow and sustained phase over 12 h. Mucoadhesion assay demonstrated interactions between NG with mucin. Moreover, NG provided photoprotection and pH stability to BR Ext. FRAP and ABTS assays confirmed that BR Ext maintained antioxidant activity into NG. Furthermore, in vitro assays using human retinal cells displayed absence of cytotoxicity as well as an efficient protection against injury agents (LPS and H2O2). NGs are a promising platform for BR Ext encapsulation, exerting controlled release for ophthalmological use.

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Development and in vitro Evaluation of Voriconazole Nanoparticle Formulation for Mucosal Application

Cited by 5 publications

References 29 publications

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Gambaran Penggunaan Obat Antipendarahan dan Antinyeri pada Pasien Rawat Inap Kanker Serviks Di Rumah Sakit X Wilayah Kota Gorontalo Periode 2021-2022

Chitosan-Based Nanogels Designed for Betanin-Rich Beetroot Extract Transport: Physicochemical and Biological Aspects

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