Development and Optimization of Sustained Release in Situ Gel for the Treatment of Ulcerative Colitis

Abstract

The objective of the research work was focused on optimization and evaluation of Mesalamine rectal in-situ gel of controlled/sustained release. This is used as anti-ulcerative colitis drug, for pediatric dose.The in-situ gel formulation were prepared by simple mixing method it's a cooling technique based on the temperature triggering system by incorporation of various polymers like Poloxamer 407 and HPMC E-50 in different proportions. The in-situ gel characteristics were evaluated for clarity, gelation time, gelation temperature, gel strength, and in-vitro drug release studies. The formulations gave an initial burst effect and followed by sustained release for 12 h. Optimized formulation showed release of drug up to 92.860% in 12 h. Optimization was done by using design expert software. The optimized formula (F3) showed no significant changes on stability studies when stored at 40ºC/75% RH for one month according to ICH guidelines.

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

“…Drug content studies were carried out in triplicate. The concentration of the drug present in the in situ gelling liquid suppository formulation was calculated from the equation obtained from the calibration curve [16] .…”