Objective: The goal behind of performing this study was to come out with an oroslippery buoyant ranitidine hydrochloride tablet to ease the swallowing process. Hence, the drug is released controllably in the stomach regardless of the effect on gastric emptying time.Materials and Methods: The core of the buoyant containing 150 mg of the drug was compressed directly, and sodium bicarbonate was employed as an effervescent agent, besides, hydroxyl propyl methyl cellulose (HPMC) polymer was utilized in different grades in the formulation process. The prepared core was immersed in the coating dispersion, which was formulated using xanthan gum (slipping agent) and Kollicoat instant release (IR) (for film formation). According to the variables in the formulation process, floating properties varies along with the release profile of the drug; therefore, investigation of the effects of variables was conducted, including polymer type and concentration in the core part, and the effect of Kollicoat IR amount as well as the level of coating.Results: According to this study, it was clearly obvious that T4 formulation, that consisted of HPMC K4M, after being dipped 2 times in dispersion of 0.3% xanthan gum and 14% Kollicoat IR, had provided an instant floating, moreover, the in vivo slipperiness was quite acceptable as well as the taste masking. Nevertheless, the percentage of drug release measured after 6 h was 90.15%.Conclusion: The resultant formulas is quite promising to take the lead as new approach to easy swallowing tablets without need of water especially for patients with swallowing problems as well as it is floating tablet that can retain the drug in gastric cavity to be continuously released to ensure its maximum absorption and may improve its bioavailability.

The present investigation was undertaken with the objective of developing fast dissolving film(s) of a tricyclic antidepressant drug amitriptyline hydrochloride in order to improve its bioavailability, optimize its therapeutic action especially when used to treat major depression and to enhance the compliance for the developmentally disable, mentally ill, elderly and pediatric patients. , the study based on cross over design using experimental animals (rabbits). The pharmacokinetic results revealed that the fast dissolving films has higher peak blood concentration (C max , 0.927µg/ml) within shorter time (T max, 2 hours), indicating rapid absorption and faster onset of action with acceptable bioavailability value. These findings suggest that the fast dissolving film containing amitriptyline hydrochloride is expected to become one of choices for the treatment of acute depression.

Objective:The goal of performing this study is to prepare an oral strip, especially designed for pediatric use that provides fast onset of action with ease of swallowing particularly for young individuals who suffer from difficulty of swallowing, in addition provides maximum therapeutic effectiveness by reducing the first pass effect. Materials and Methods:The oral strip was prepared by solvent casting technique through using different sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Maltodextrin (MD) was added as the secondary polymer in different ratios to optimize the release parameters, and disintegration time (DT), three different plasticizers were employed (propylene glycol, dibutyl phthalate, and glycerin) to boost the film forming polymer characteristics.Results: From this study, it is obvious that F10 which composed of HPMC as a main polymer and MD as a secondary polymer in ratio 2:1, respectively, provides adequate physicochemical characteristics, in vitro/in vivo DT DT (40/36 s), respectively, nevertheless a satisfactory release parameters as (59.9%) released at 2 min and 80% of drug released at 14.8 min. Conclusion:The optimized formula is pretty encouraging to originate an oral strip that provides ease of administration, fast onset of action with wide acceptance for the pediatric population.

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