Optimization and Evaluation of Chlorpheniramine Maleate Oral Strip for Pediatric Use

Abstract

Objective:The goal of performing this study is to prepare an oral strip, especially designed for pediatric use that provides fast onset of action with ease of swallowing particularly for young individuals who suffer from difficulty of swallowing, in addition provides maximum therapeutic effectiveness by reducing the first pass effect. Materials and Methods:The oral strip was prepared by solvent casting technique through using different sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Maltodextrin (MD) was added as the secondary polymer in different ratios to optimize the release parameters, and disintegration time (DT), three different plasticizers were employed (propylene glycol, dibutyl phthalate, and glycerin) to boost the film forming polymer characteristics.Results: From this study, it is obvious that F10 which composed of HPMC as a main polymer and MD as a secondary polymer in ratio 2:1, respectively, provides adequate physicochemical characteristics, in vitro/in vivo DT DT (40/36 s), respectively, nevertheless a satisfactory release parameters as (59.9%) released at 2 min and 80% of drug released at 14.8 min. Conclusion:The optimized formula is pretty encouraging to originate an oral strip that provides ease of administration, fast onset of action with wide acceptance for the pediatric population.

Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films

“…It resulted in the significantly lowest percent elongation and folding endurance and highest elastic modulus (Figure 2(a,b,e,f)). This was in accordance with the findings of Mahmood et al who made an optimization and evaluation of chlorpheniramine maleate oral strip for pediatric use (Mahmood et al, 2018).…”

“…This could be due to hydrophobicity of DBP so it does not undergo leaching from the film in contrast to the other two hydrophilic counterparts PG and PEG. PG and PEG are water soluble and diffuse out from the films in watery media creating voids in the film through which distribution of liquid happens to enable film breaking down leading to faster dissolution of drug (Mahmood et al, 2018 ). Films containing PEG had significantly higher Q5 and significantly lower Q15 than those contain PG ( Figure 2(c,d) ).…”

Characterization of modified sorghum starch and its use as a film-forming polymer in orally dissolving film formulations with glycerol as a plasticizer

“…This occurs due to the increase in polymer concentration. MDX, which has a high solubility in water and aids water penetration into the film structure, provides a shorter disintegration time [24,25]. Therefore, when the concentrations of polymer and plasticizer are high, the disintegration time is short.…”

Oral Thin Films As a Remedy for Noncompliance in Pediatric and Geriatric Patients

“…Several papers have been published in which solvent casting was used to obtain films for paediatric or geriatric applications. For example, Mahmood and co-workers [36], and Teja and co-workers [37] successfully formulated chlorpheniramine maleate oral thin film for paediatric application to aid swallowability as well as improve therapeutic effectiveness using the solvent casting method.…”