Development and Performance of an Albumin-Creatinine Ratio Assay on the Afinion AS100 Analyzer

Kvam, Catrine; Dworsky, Ellen; Campbell, Andrew T.; Karlson, Jan Roger; Jernberg, Espen; Swensen, Monica Hvidsten; Holtlund, Jostein; Tøn, Hege; Faaren, Arne Ludvig; Nordhei, Arne Kristian; Frantzen, Frank

doi:10.1097/poc.0b013e3181971d57

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Glycosylated haemoglobin (HbA 1c ) was also measured with the Afinion AS100 Analyzer. The validity of HbA 1c and ACR measurements by the Afinion AS100 Analyzer has previously been documented . Moreover, we ensured ongoing validity and exact precision of the Afinion using HbA 1c and ACR control samples each day prior to any use in the participants.…”

Section: Methodsmentioning

confidence: 77%

“…The validity of HbA 1c and ACR measurements by the Afinion AS100 Analyzer has previously been documented. 10,11 Moreover, we ensured ongoing validity and exact precision of the Afinion using HbA 1c and ACR control samples each day prior to any use in the participants. Neither ACR nor HbA 1c had been measured in any of the participants prior to the study.…”

Section: Methodsmentioning

confidence: 99%

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Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

Rasmussen

Nordin

Thomsen

et al. 2015

J of Clinical Hypertension

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The objective of this cross-sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub-Saharan Africa (SSA). Urine albumin-creatinine ratio, glycated hemoglobin (HbA 1c ), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were codiagnosed with diabetes mellitus (DM Only dysregulated DM and age were the conventional risk markers that seemed to suggest albuminuria among patients with hypertension in rural SSA. J Clin Hypertens (Greenwich).

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Section: Methodsmentioning

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

Rasmussen

Nordin

Thomsen

et al. 2015

J of Clinical Hypertension

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“…Low-density lipoprotein (LDL) concentrations were calculated using the Friedewald formula [ 21 ]. Urinary albumin was quantified using a solid-phase immunochemical assay and urinary creatinine by an enzymatic colourimetric test in a fully automated Afinion AS100 Analyzer (Axis-Shield, Norway) [ 22 ], and then the urinary albumin-to-creatinine ratio (UACR) (expressed as mg/g creatinine) was calculated.…”

Section: Methodsmentioning

confidence: 99%

Frailty and Nutritional Status among Urban Older Adults in South India

Thakur

Chitra

Kumar

et al. 2020

Journal of Aging Research

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The purpose of this study was to assess the prevalence of frailty and nutritional status among older adults. This population-based cross-sectional study was conducted in 163 subjects aged 60–88 years, from Hyderabad City, South India. Data were obtained on sociodemographic details and anthropometry and biochemical parameters. Dietary intake was assessed by a three-day 24 h dietary recall, and the probability of adequacy (PA) was calculated using the estimated average requirements. Frailty indicators were as follows: handgrip strength was measured by using a Jamar dynamometer, gait speed was measured by a ten-meter length walk test, and low physical activity level, weight loss, and exhaustion were assessed using a questionnaire. Among the study population, 20% of the participants were frail and 80% were nonfrail. The prevalence of frailty is higher in older (30.1%) than the younger (12.2%) age groups, and it is more so in women (32.4%) than in men (10.1%). The lower educational status and income were associated with frailty. The PA of most of the nutrients was low in the frail group. Noticeably, the mean PA (MPA) across the fourteen micronutrients was significantly higher in nonfrail (38%) compared to the frail group (25%). The prevalence of frailty was higher in the lowest tertile of most of the food groups and nutrient intake compared to the highest tertile. The study revealed a 20% prevalence of frailty among urban older adults and provided evidence that inadequate intake of nutrients is independently associated with frailty.

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“…The Alere Afinion™ AS100 is a simple, robust, convenient and safe analyser. 16 Furthermore, the Alere Afinion™ AS100 may be a good POC analyser for screening in older adults within a high HIV prevalence setting for early detection and diagnosis of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…14 Jain et al 15 confirmed that the Afinion™ AS100 analyser provides a platform for the analysis of multiple analytes with good comparability to the standard laboratory method (Cholestech LDX). Kvam et al 16 also found that the Afinion™ AS100 was able to produce a good correlation when compared to another POCT DCA2000 for microalbumin/ creatinine as well as when compared to the automated laboratory modular albumin and creatinine methods. Abbai et al 14 recently found a good correlation between the Alere Afinion™ AS100 analyser and the ABX Pentra 400 analyser for the measurement of glycated haemoglobin (hbA1c) and lipid levels in older adults in Durban, South Africa.…”

Section: Introductionmentioning

confidence: 94%

Evidence for the use of the Alere Afinion™ AS100 for measuring the levels of C-reactive protein in an elderly South African population

Mpofana

Nyirenda

Abbai

2020

The Journal of Medical Laboratory Science and Technology of Sou

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Introduction: This study evaluated the performance of the Alere Afinion™ AS100 analyser for the measurement of C-reactive protein (CRP) levels in a population of older adults from South Africa. Methods: This study was a sub-study of the Sexual Health, HIV infection and comorbidity with non-communicable diseases among Older Persons (SHIOP) study. The median age of SHIOP participants was 61 years (interquartile range 12). Serum samples collected through SHIOP were used to measure CRP levels on the Alere Afinion™ AS100 (Point-of-care) and ABX Pentra 400 (reference method), respectively. Bland–Altman analysis and Lin’s concordance correlation coefficients were used to assess the agreement between the two analysers. Results: A total of 183 serum samples were tested in the study. The Alere Afinion™ AS100 median values for CRP were 9.5 mg/L and 11.5 mg/L in women and men respectively (p = 0.275). The ABX Pentra 400 median levels were lower with 5.6 mg/L and 3.6 mg/L for women and men (p = 0.027), respectively. Bland–Altman analysis and linear regression analysis showed an excellent correlation between the Pentra and Afinion analysers, with a Lin’s concordance correlation coefficient of 0.971. The Alere Afinion™ AS100 was able to correctly classify > 90% (165/183) of the CRP results when compared to the ABX Pentra 400. Conclusion: This study showed that the Alere Afinion™ AS100 had an excellent correlation with a standard laboratory method. However, the Afinion™ AS100 did not correlate well at elevated CRP levels. This may not be clinically significant since the cut-points for CVD risk are at much lower levels.

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Development and Performance of an Albumin-Creatinine Ratio Assay on the Afinion AS100 Analyzer

Cited by 8 publications

References 7 publications

Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

Frailty and Nutritional Status among Urban Older Adults in South India

Evidence for the use of the Alere Afinion™ AS100 for measuring the levels of C-reactive protein in an elderly South African population

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