2019-Novel Coronavirus (2019-nCOV), enclosed large genome positive-sense RNA virus characterized by crown-like spikes that protrude from their surface, and have a distinctive replication strategy. The 2019-nCOV belongs to the Coronaviridae family, principally consists of virulent pathogens showing zoonotic property, has emerged as a pandemic outbreak with high mortality and high morbidity rate around the globe and no therapeutic vaccine or drugs against 2019-nCoV are discovered till now. In this study, in silico methods and algorithms were used for sequence, structure analysis and molecular docking on M pro of 2019-nCOV. The co-crystal structure of 2019-nCOV protease, 6LU7 have $99% identity with SARS-CoV protease. The 6LU7 residues, Cys145 and His164 are playing a significant role in replication and are essential for the survival of 2019-nCOV. Alongside, 2019-nCOV M pro sequence is non-homologous to human host-pathogen. Complete genome sequence analysis, structural and molecular docking results revealed that Remdesivir is having a better binding affinity with-8.2 kcal/ mol than the rest of protease inhibitors, and peptide. Remdesivir is strongly forming h-bonds with crucial M pro residues, Cys145, and His164. Further, MD simulation analysis also confirmed, that these residues are forming H-bond with Remdesivir during 100 ns simulations run and found stable ($99%) by RMSD and RMSF. Thus, present in silico study at molecular approaches suggest that, Remdesivir is a potent therapeutic inhibitor against 2019-nCoV.

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Adolescence appears to be the next available critical period to improve inadequacies in nutrition, growth, and development from childhood. In this analysis, we describe the dietary and nondietary determinants of nutritional status among adolescent girls and adult women residing in rural areas of India. We used data pertaining to 3930 adolescents (10–19 years) and 11,058 adult women (20–49 years) from the National Nutrition Monitoring Bureau Survey, 2011–2012 database. Logistic regression analysis was conducted to understand the effects of various individual‐ and household‐level determinants of thinness and underweight among adolescents and adult women, respectively. Almost one‐third of the adolescents and adult women were undernourished. Factors other than dietary adequacy and diversity had a greater impact on undernutrition in both the adolescents and adult women. The nondietary determinants (e.g., higher age group, higher household wealth status, access to improved water, better maternal work status, and living in better type of houses) predicted good nutritional status in the adolescent girls. In addition, the women's own higher education and household occupation status and better sanitation facilities improved undernutrition in adult women. Therefore, India needs multipronged strategies along with dietary interventions and effective implementation programs to achieve good health and well‐being of adolescents and adult women.

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