Development and physicochemical characterization of clindamycin resinate for taste masking in pediatrics

Daihom, Baher; Alayoubi, Alaadin; Ma, Dejian; Wang, Lijia; Mishra, Sanjay R.; Helms, Richard A.; Almoazen, Hassan

doi:10.3109/03639045.2016.1160104

Cited by 17 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristic sharp endothermic transition ( T m ) around 138.41 °C is mainly related to clindamycin’s melting point (142 °C, as previously reported by [ 19 ]). Another endothermic peak appeared at 161.3 °C which could be related to clindamycin’s glass transition temperature ( T g ) [ 20 ]. Finally, a mild endothermic peak also appeared at 329 °C, which may be attributed to drug decomposition.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

et al. 2017

View full text Add to dashboard Cite

A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios with different sets of drug concentrations were prepared. These were UV scanned initially and after three and seven days of storage at 25 °C. Using the calibration model, the drug recovery percent was estimated and a decrease in concentration of 10% or more from initial concentration was considered to indicate instability. PLS models with PC3 (for Ag) and PC2 (for Ch) showed a good correlation between actual and found values with root mean square error of cross validation (RMSECV) of 0.00284 and 0.01228, and calibration coefficient (R2) values of 0.996 and 0.942, respectively. The average drug recovery percent after three and seven days was 98.1 ± 2.9 and 95.4 ± 4.0 (for Ag), and 97.3 ± 2.1 and 91.4 ± 3.8 (for Ch), which suggests more drug compatibility with an Ag than a Ch polymer. Conventional techniques including DSC, XRD, FTIR, and in vitro minimum inhibitory concentration (MIC) for (1:1) drug–polymer mixtures were also performed to confirm clindamycin compatibility with Ag and Ch polymers.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Drug release from the drug resin complex depends on the environment pH and ionic strength within the gastrointestinal tract, as well as on the properties of the resin (19). The pH, ionic species and strength effects on drug dissolution from MR-ODT were studied.…”

Section: Dissolution Studymentioning

confidence: 99%

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

Wang

Shi

et al. 2018

Acta Pharmaceutica

View full text Add to dashboard Cite

The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compression and were optimized using the response surface method. Optimized orally fast-disintegrating tablets disintegrated within 18 s. The pH dependence of mosapride release from the tablet decreased drug dissolution in simulated saliva, whereas it promptly released in the pH 1.0 solution. The data reported herein clearly demonstrate that tablets containing the mosapride-Amberlite® IRP 88 complex for oral disintegration could be particularly useful for patients with swallowing difficulties.

show abstract

“…The other problem is the short duration of drug action, thereby, the drug should be applied two times daily 1 . In addition, CLN may have unpleasant odor which cannot be masked via commercial products 6 . As a result, limitations of conventional topical preparations of CLN may lead to poor patient compliance and reduction in treatment efficacy.…”

Section: Introductionmentioning

confidence: 99%

Optimization of entrapment efficiency and release of clindamycin in microsponge based gel

Khattab

Nattouf

2021

Sci Rep

View full text Add to dashboard Cite

The aim of the present study was to formulate clindamycin (CLN) as a microsponge based gel to release the drug in a controlled manner and reduce the side effects in the treatment of acne. Since this method requires poor water solubility of the drug to be loaded in particles, therefore, conversion of the hydrochloride salt to free base was done. By using an emulsion solvent diffusion method, we made six different formulations of microsponges containing CLN-free base by changing the proportions of polymer, emulsifier and the pH of the external phase. These formulations were studied for physical characterization and for drug- polymer interactions. The physical characterization showed that microsponge formulations coded by C5, C6 resulted in a better loading efficiency and production yield and their particle size was less than 30 µm. Scanning electron microscopy images showed the microsponges porous and spherical. C5, C6 microsponge formulation was prepared as gel in Carbopol and in vitro evaluated. The microsponge formulation gel C8 was found to be optimized. C8 released 90.38% of drug over 12 h and showed viscosity 20,157 ± 38 cp, pH of 6.3 ± 0.09 and drug content of 99.64 ± 0.04%. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed no significant interactions between excipients and drug.

show abstract

Development and physicochemical characterization of clindamycin resinate for taste masking in pediatrics

Abstract: The clindamycin stable complex with IER (Amberlite IRP69) has the potential for further development as a compatible pediatric liquid formulation (suspension) or a fast disintegrating tablet.

Cited by 17 publications

References 16 publications

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

Optimization of entrapment efficiency and release of clindamycin in microsponge based gel

Contact Info

Product

Resources

About