2011
DOI: 10.1007/s13233-011-0205-5
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Development and physicochemical evaluation of chondroitin sulfate-poly(ethylene oxide) hydrogel

Abstract: Novel chondroitin sulfate (CS) -poly(ethylene oxide) (PEO) hydrogel was synthesized and evaluated by a mechanism of self cross-linking of CS derivative with PEO with hexa-thiols (PEO-SH). A derivative of CS was synthesized by the sequential grafting of adipic acid dihydrazide (ADH) and acrylic acid: chemical grafting of ADH to the carboxylic acid in CS (CS-ADH) followed by grafting of the acrylic acid to the free amine groups in the CS-ADH (CS-ADH-Ac). The synthesis of CS-ADH-Ac molecules was confirmed by obse… Show more

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Cited by 8 publications
(10 citation statements)
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“…Chitosan-spacer-PEO hydrogel was synthesized by mixing the above two solutions into a 1 mL disposal vial via the Michael type addition reaction without further treatment. Their hydrogelation times were determined by employing the methods of both vial tilting 23 and rheological measurement as reported by our previous reports. 12,23,37 In vitro Cell Behaviors on/in Chitosan-PEO Hydrogel.…”
Section: Methodsmentioning
confidence: 99%
“…Chitosan-spacer-PEO hydrogel was synthesized by mixing the above two solutions into a 1 mL disposal vial via the Michael type addition reaction without further treatment. Their hydrogelation times were determined by employing the methods of both vial tilting 23 and rheological measurement as reported by our previous reports. 12,23,37 In vitro Cell Behaviors on/in Chitosan-PEO Hydrogel.…”
Section: Methodsmentioning
confidence: 99%
“…Fabrication of CS-PEO hydrogel was previously reported by us in detail. 5 Briefly, after acrylation of CS (CS-acrylate) with sequential grafting of ADH and acrylic acid via EDC chemistry, synthesis of the CS-PEO hydrogel was proceeds through a Michael type addition reaction between precursors such as CS-acrylate and PEO with thiols. Synthesis of CS-acrylate and CS-PEO hydrogel has been described in Figure 1 and reported in detail in our previous report.…”
Section: Methodsmentioning
confidence: 99%
“…Synthesis of CS-acrylate and CS-PEO hydrogel has been described in Figure 1 and reported in detail in our previous report. 5,6 Evaluation of Gelation Time. Measurement of gelation times was processed by a vial tiling method by tilting the mixture solution in a vial over time.…”
Section: Methodsmentioning
confidence: 99%
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