Synthesis of In situ chondroitin sulfate hydrogel through phosphine-mediated Michael type addition reaction

Jo, Seongyeon; Kim, Su-Mi; Noh, Insup

doi:10.1007/s13233-012-0138-7

Cited by 29 publications

(26 citation statements)

References 26 publications

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“…An exothermic peak above 200 °C appeared in the pure sample and showed the decomposition of polymer [shown in Figure (B)]. The DSC curves of the prepared hydrogel (CSMA) showed a different pattern from the pure polymer (CS) and a strong endothermic peak at a temperature of 250 °C, revealing that the breakdown of the polymeric backbone led to the degradation of the polymeric network . Conclusively, DSC analysis proved that the developed polymeric hydrogel system was more stable than the individual polymer contents, as shown in Figure (B).…”

Section: Resultsmentioning

confidence: 92%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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The purpose of this study was to develop and characterize chemically crosslinked chondroitin sulfate-co-poly(methacrylic acid) (CSMA) hydrogels for colon targeting of oxaliplatin (OXP) to treat colorectal cancer. CSMA hydrogels were synthesized by freeradical polymerization. Chondroitin sulfate was chemically crosslinked with methacrylic acid in an aqueous medium. Ammonium peroxodisulfate and N,N-methylene bisacrylamide were used as the initiator and crosslinker, respectively. Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy studies were performed to characterize the fabricated polymeric system. The pH-sensitive characteristics of the hydrogels were evaluated by swelling dynamics and equilibrium swelling ratio measurements at pH 1.2 and 7.4. A toxicity study of the developed formulations was also conducted on rabbits to determine the toxicity of the drug-carrier system to the biological system. The characterization studies confirmed the formation of a new polymeric network. A high OXP loading and higher drug release was observed at pH 7.4. The toxicity study confirmed that the developed formulations were nontoxic to the biological system.

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Section: Resultsmentioning

confidence: 92%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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“…Hydrogel for animal experiments was prepared from low molecular weight hyaluronic acid (low HA, MW 340kd) as described previously [27]. Briefly, low HA was reacted with adipic acid dihydrazide using N-(3-diethylpropyl)-N-ethylcarbodiimide (EDC) as a cross-linking agent at room temperature to synthesize HA-ADH.…”

Section: Hydrogel Preparation and Biocompatibility Test On Ha Hydrogelmentioning

confidence: 99%

A platform technique for growth factor delivery with novel mode of action

et al. 2014

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“…Newer methods to generate porous scaffolds using biodegradable polymers include using gas forming of porogens (ammonium bicarbonate particles). Injectable hydrogels using click chemistry (high yielding, wide in scope molecules) have also shown to be highly advantageous for local delivery of bioactive molecules, ease of handing and reduced invasiveness, these techniques have been demonstrated to be potentially used in 3D bioprinting ( Jo, Kim & Noh, 2012 ). The use of hand held 3D matrix printing using a bio-pen has allowed for in-situ printing and repair to take place.…”

Section: Biomaterialsmentioning

confidence: 99%

The role of biomaterials in the treatment of meniscal tears

Kean

Brown

Chapman

2017

PeerJ

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Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent osteoarthritis. To this end, meniscus repair and regeneration is of particular interest from the biomaterial, bioengineering and orthopaedic research community. Even though meniscal research is previously of a considerable volume, the research community with evolving material science, biology and medical advances are all pushing toward emerging novel solutions and approaches to the successful treatment of meniscal difficulties. This review presents a tactical evaluation of the latest biomaterials, experiments to simulate meniscal tears and the state-of-the-art materials and strategies currently used to treat tears.

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Synthesis of In situ chondroitin sulfate hydrogel through phosphine-mediated Michael type addition reaction

Cited by 29 publications

References 26 publications

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

A platform technique for growth factor delivery with novel mode of action

The role of biomaterials in the treatment of meniscal tears

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