According to the American Society of Addiction Medicine (ASAM) and the World Health Organization (WHO), chemical dependence consists of a chronic and progressive disease. But without organized etiopathogenesis, we carried out in clinical practice, description of new specific neurological and clinical states, based on the brain physiology common to all human beings, which reorganized all Addiction Medicine, and the discovery of childhood, adult and elderly Z Syndromes, Syndrome Zoé, which are secondary to simultaneous neurological dysfunctions of human neuro-development, such as: 1) neurological deficit of familial asynchrony (DNAF), which generates in response 2) fear adaptation neuro behavior (amygdalian and limbic), 3) unconscious reproduction of familial asynchrony due to neurobiological psychodynamics, which generates the 4) hypodopaminergic neurological state or RDS described by Blum et al.