Four flat-sheet submerged anaerobic membrane bioreactors ran for 242 days on a simulated domestic wastewater with low Chemical Oxygen Demand (COD) and high suspended solids. Organic loading was maintained around 1.0 g COD L−1 day−1, while solids retention time (SRT) was varied from 20–90 days. This was achieved at a constant membrane flux, maintained by adjusting transmembrane pressure (TMP) in the range 1.8-9.8 kPa. Membrane fouling was assessed based on the required TMP, with mixed liquors characterised using capillary suction time, frozen image centrifugation and quantification of extracellular polymeric substances (EPS). SRT had a significant effect on these parameters: fouling was least at an SRT of 30 days and highest at 60 days, with some reduction as this extended to 90 days. Operation at SRT <30 days showed no further benefits. Although operation at a short SRT was optimal for membrane performance it led to lower specific methane productivity, higher biomass yields and higher effluent COD. Short SRT may also have accelerated the loss of essential trace elements, leading to reduced performance under these conditions. A COD-based mass balance was conducted, including both biomass and methane dissolved in the effluent.