Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China

Wen, Shuyu; Qiao, Weihua; Yuan, Zhang; Dong, Nianguo

doi:10.21037/atm.2020.03.165

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Consecutive patients aged ≥ 60 years, who received at least one valve replacement, were retrospectively included in the study between January 2010 and December 2017, and were prospectively followed up for one year. Exclusion criteria were: ( 1 ) receiving lipid-lowering therapy; and ( 2 ) no preoperative LDL-C results.…”

Section: Methodsmentioning

confidence: 99%

“…Valvular heart disease (VHD) remains to be a major burden worldwide. It was estimated that more than 42 million people worldwide suffered from VHD ( 1 ). In developing counties, due to the high incidence of rheumatic heart disease, as well as expanding of the aging population (age ≥ 60 years), hence, with the increase in the incidence of degenerative valvular disease ( 2 , 3 ), more attention should be drawn to VHD.…”

Section: Introductionmentioning

confidence: 99%

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Low-Density Lipoprotein Cholesterol and Mortality Risk in Elderly Patients Undergoing Valve Replacement Surgery: A Propensity Score Matching Analysis

Tan

et al. 2022

Front. Nutr.

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BackgroundThe prognostic value of low-density lipoprotein cholesterol (LDL-C) in elderly patients is controversial. This study aimed to elucidate the relationship between the preoperative LDL-C and adverse outcomes in elderly patients undergoing valve replacement surgery (VRS).MethodsA total of 2,552 aged patients (age ≥ 60 years) undergoing VRS were retrospectively recruited and divided into two groups according to LDL-C level on admission: low LDL-C (<70 mg/dL, n = 205) and high LDL-C groups (≥ 70 mg/dL, n = 2,347). The association between the preoperative LDL-C with in-hospital and one-year mortality was evaluated by propensity score matching analysis and multivariate analysis.ResultsThe mean age was 65 ± 4 years and 1,263 (49.5%) were men. Patients in the low LDL-C group were significantly older (65.9 ± 4.6 vs. 64.9 ± 4.1, p = 0.002), with more male (65.4 vs. 48.1%, p < 0.001), higher alanine transaminase (ALT) (21 vs. 19, p = 0.001), lower serum albumin (35.3 ± 4.6 vs. 37.1 ± 4.1, p < 0.001), higher serum creatinine (92.2 ± 38.2 vs.84.6 ± 26.1, p = 0.006), lower lymphocyte count (1.7 ± 0.7 vs. 1.9 ± 0.6, p < 0.001), lower hemoglobin (121.9 ± 22.3 vs. 130.2 ± 16.5, p < 0.001), lower platelet count (171.3 ± 64.3 vs. 187.7 ± 58.7, p < 0.001), lower prognostic nutrition index (44 ± 6.2 vs. 46.7 ± 5.8, p < 0.001), and more severe tricuspid regurgitation (33.7 vs. 25.1%, p = 0.008). The rates of in-hospital death (11.2 vs. 3.7%, p < 0.001) and major adverse clinical events (17.6 vs. 9.6%, p < 0.001) were significantly higher in the low LDL-C group. The cumulative one-year death rate was significantly higher in the low LDL-C group (Log-Rank = 16.6, p < 0.001). After matching analysis and multivariate analysis, no association between LDL-C level and adverse outcomes was detected (all p > 0.05).ConclusionOur study did not support the negative relationship between LDL-C level and mortality risk in elderly patients undergoing VRS.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-Density Lipoprotein Cholesterol and Mortality Risk in Elderly Patients Undergoing Valve Replacement Surgery: A Propensity Score Matching Analysis

Tan

et al. 2022

Front. Nutr.

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“…In the past 2 decades, the application of BHV has surpassed MHV. Rapid advances in the field of transcatheter aortic valve replacement (TAVR) also contributed to the extending scope and appreciation for BHV (Wen et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification

et al. 2022

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Valve replacement is the main therapy for valvular heart disease, in which a diseased valve is replaced by mechanical heart valve (MHV) or bioprosthetic heart valve (BHV). Since the 2000s, BHV surpassed MHV as the leading option of prosthetic valve substitute because of its excellent hemocompatible and hemodynamic properties. However, BHV is apt to structural valve degeneration (SVD), resulting in limited durability. Calcification is the most frequent presentation and the core pathophysiological process of SVD. Understanding the basic mechanisms of BHV calcification is an essential prerequisite to address the limited-durability issues. In this narrative review, we provide a comprehensive summary about the mechanisms of BHV calcification on 1) composition and site of calcifications; 2) material-associated mechanisms; 3) host-associated mechanisms, including immune response and foreign body reaction, oxidative stress, metabolic disorder, and thrombosis. Strategies that target these mechanisms may be explored for novel drug therapy to prevent or delay BHV calcification.

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“…The leaflets of the porcine heart valve are highly anisotropic, with radial elasticity almost four times stronger than the circumferential elasticity [14]. As shown in previous reports, porcine heart valve is an important research object [15,16]. For example, Dai et al combined degradable polyethylene glycol (PEG) hydrogel with decellularized porcine aortic heart valve to prepare a composite scaffold to promote the differentiation of bone mesenchymal stem cells (BMSCs) into heart valve interstitial-like cells [17].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical scaffolds of decellularized heart valves modified by electrospun polylactic acid

Wang

Chen

Wang

et al. 2022

Preprint

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Enhancing the mechanical properties and cytocompatibility of decellularized heart valves is the key to promote the application of biological heart valves. In order to further improve the mechanical properties, the electrospinning and non-woven processing methods are combined to prepare the polylactic acid (PLA)/decellularized heart valve nanofiber-reinforced sandwich structure electrospun scaffold. The effect of electrospinning time on the performance of decellularized heart valve is investigated from the aspects of morphology, mechanical properties, softness, and biocompatibility of decellularized heart valve. Results of the mechanical tests show that compared with the pure decellularized heart valve, the mechanical properties of the composite heart valve were significantly improved with the tensile strength increasing by 108% and tensile strain increased by 571% when the electrospinning time exceeded 1 h. In addition, with this electrospinning time, the composite heart valve has a certain promoting effect on the human umbilical vein endothelial cells proliferation behavior. This work provides a promising foundation for tissue heart valve reendothelialization to lay the groundwork for organoid.

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Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China

Cited by 7 publications

References 22 publications

Low-Density Lipoprotein Cholesterol and Mortality Risk in Elderly Patients Undergoing Valve Replacement Surgery: A Propensity Score Matching Analysis

Low-Density Lipoprotein Cholesterol and Mortality Risk in Elderly Patients Undergoing Valve Replacement Surgery: A Propensity Score Matching Analysis

Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification

Biomechanical scaffolds of decellularized heart valves modified by electrospun polylactic acid

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