Development and validation of a liquid chromatographic method for determination of related-substances of mosapride citrate in bulk drugs and pharmaceuticals

Rao, R. Nageswara; Nagaraju, D.; Alvi, Syed N.; Bhirud, S. B.

doi:10.1016/j.jpba.2004.08.004

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…The mass transition m/z 422 → 198 for mosapride confirmed several previous reports [15,22,23]. The fragmentation pathways have been described previously in several papers [15,22,26].…”

Section: Methods Developmentsupporting

confidence: 88%

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Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Aoki¹,

Hakamata

Igarashi³

et al. 2007

Journal of Chromatography B

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“…The mass transition m/z 422 → 198 for mosapride confirmed several previous reports [15,22,23]. The fragmentation pathways have been described previously in several papers [15,22,26].…”

Section: Methods Developmentsupporting

confidence: 88%

“…High-performance liquid chromatography (HPLC) with UV detection was used to determine mosapride in bulk drugs or pharmaceutical preparations [13][14][15]. The enantioseparation and enantioselective determination by HPLC with UV detection [16,17] or HPLC with fluorometric detection [18] were also reported.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Aoki¹,

Hakamata

Igarashi³

et al. 2007

Journal of Chromatography B

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“…The mobile phase was a solution of HPLC-grade methanol, water, glacial acetic acid and triethylamine at a ratio of 1600:400:05:1 (RAO et al, 2004) which was injected into the system at a flow rate of 0.8ml/min after being filtered through a 0.45mm membrane filter. The column temperature was kept at 30°C, and the spectrophotometer was set to a detection wavelength of 274nm.…”

Section: Evaluation Of Tabletsmentioning

confidence: 99%

Development and evaluation of mosapride citrate orally disintegrating tablets for dogs

2016

Cienc. Rural

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HPLC‐fluorescence assay for measuring mosapride in small volumes of rat plasma

Cheng

Chang

Chou

2009

Biomedical Chromatography

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A simple and sensitive HPLC-fluorescence assay was developed for the determination of a gastroprokinetic agent mosapride in small volumes of rat plasma. Samples (50 microL) were treated with 200 microL of the internal standard solution (cisapride, 0.1 microg/mL in acetonitrile). Chromatographic separation was achieved on a C(18) column by gradient elution with the mobile phase of acetonitrile-water containing 20 mM potassium dihydrogen phosphate, at a flow rate of 1 mL/min. Fluorescence was measured with excitation and emission set at 315 and 354 nm, respectively. The retention time was about 16 min for cisapride and 20 min for mosapride. No endogenous substances were found to interfere. The calibration curve was linear from 0.015 to 10 microg/mL. The lower limit of quantification was 0.015 microg/mL. The intra- and inter-day precision expressed as relative standard deviation did not exceed 7.7%, and the accuracy was within 4.7% deviation of the nominal concentration. The method was used successfully to investigate the disposition kinetics of mosapride in rats.

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Development and validation of a liquid chromatographic method for determination of related-substances of mosapride citrate in bulk drugs and pharmaceuticals

Cited by 8 publications

References 9 publications

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Development and evaluation of mosapride citrate orally disintegrating tablets for dogs

HPLC‐fluorescence assay for measuring mosapride in small volumes of rat plasma

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