Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections

Abstract

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Quantification of 15 Antibiotics Widely Used in the Critical Care Unit with a LC-MS/MS System: An Easy Method to Perform a Daily Therapeutic Drug Monitoring

“…The results and timing at which the samples were drawn were listed in Table 4. The concentrations were compared to reference values reported in the literature [7,31,33,36]. During this period, 27 measurements of cefepime were performed.…”

“…Many analytical procedures were developed for the TDM of antibiotics. While some publications proposed the analysis of one class of antibiotics, such as beta-lactams [20,26], oxazolidinone [27,28], or daptomycin [29,30], others reported methods for the concomitant analysis of several classes of antibiotics [31][32][33][34][35][36][37]. Appendix 5 of the Wellington ICU Drug Manual depicted an overview of antibiotic sensitivity of different bacteria incriminated in the intensive care unit [38].…”

Simultaneous Measurement of 11 Antibiotics for Use in the Intensive Care Unit by Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

“…Current methods for measuring antibiotics include liquid chromatography–mass spectrometry (LC-MS), 16–22 high-performance LC (HPLC) with UV detection, 23 immunoassays, 24,25 and microbiological assays. 26,27 The method with the highest sensitivity and capacity for high turnaround is LC-MS, which can analyze multiple compounds in a single sample.…”

A UPLC–MS/MS method for simultaneous determination of nine antiepileptic drugs in human plasma and its application in TDM

“…Therefore, it is necessary to develop new methods, which should also highlight the characteristics of TDM work on the basis of ensuring sensitivity and specificity. On the one hand, the new method should be able to monitor as many drugs as possible simultaneously to minimize healthcare costs (LLopis et al, 2020). On the other hand, it should ensure TDM results are obtained quickly by optimizing sample processing and analyzing methods to guide doctors to adjust treatment regimens for patients (Sogawa, Saita, & Yamamoto, 2019).…”