Development and Validation of a Novel Tool for Assessing the Environmental Impact of 3D Printing Technologies: A Pharmaceutical Perspective

Youssef, Souha H.; Abdella, Sadikalmahdi; Garg, Sanjay

doi:10.3390/pharmaceutics14050933

Cited by 7 publications

(2 citation statements)

References 76 publications

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“…Two articles in our analysis did not focus on biologics. One of these papers, Youssef et al (2022), reported a novel environmental impact assessment tool (Index of Greenness Assessment of Printed Pharmaceuticals (iGAPP)) for 3D printing in the pharmaceutical sector, and specifically 3D printing that personalises therapeutics through individually adjusted doses (94). The second paper, Sharma…”

Section: Resultsmentioning

confidence: 99%

Environmental impacts associated with the manufacturing of personalised medicines: a scoping review

Al-Jarshawi¹,

Lucassen²,

Samuel³

2023

Preprint

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This report presents the findings of a project funded by UCL’s Future Targeted Healthcare Manufacturing Hub. This Hub aims to explore the challenges associated with manufacturing personalised medicines. Personalised medicines aim to move therapies from population-based, “one-size-fits-all” approaches (medicines designed for use by a population) to stratified approaches (medicines targeted to specific sub-populations based on particular (e.g., molecular/genetic) characteristics), and ultimately to approaches whereby therapeutic interventions are tailored to the specific molecular characteristics of one individual. This move has implications for medicines manufacturing processes. These processes have typically relied on forecasted demand, but as medicines become increasingly targeted to an individual’s characteristics, manufacturing approaches need to change. For example, for therapeutic interventions tailored to one individual, the manufacturing process has to wait until the individual’s molecular profile has been determined so that this information can be incorporated into therapeutic production. Other aspects of personalised medicine–such as the use of wearable sensors and 3D printing to customise medication dosages–may also require different approaches to manufacturing. The economic, social, and environmental aspects of any innovation are a necessary component of decision-making about implementation and use. This is the premise of sustainable development. In this report, we aim to better understand how the adverse environmental costs associated with personalised medicines manufacturing are being considered in the academic literature.

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Section: Resultsmentioning

confidence: 99%

Environmental impacts associated with the manufacturing of personalised medicines: a scoping review

Al-Jarshawi¹,

Lucassen²,

Samuel³

2023

Preprint

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“…The powder is finally sintered by softening a thermoplastic polymer [ 36 ]. A major advantage of this technology is the single-step printing process accompanied by high resolution without using an organic solvent [ 37 ]. However, it still retains the possibility of pharmaceutical agent degradation as a result of laser sintering [ 38 ].…”

Section: Techniques For Fabricating Drug Delivery Vehiclesmentioning

confidence: 99%

Drug Delivery Systems in Regenerative Medicine: An Updated Review

et al. 2023

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Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder their benefits. Moreover, advances in biotechnology resulted in the development of a new generation of molecules with a short half-life that necessitates frequent administration. In this context, controlled release systems are required to enhance treatment efficacy and improve patient compliance. Innovative drug delivery systems are promising tools that protect therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. The present review provides an overview of different approaches used for drug delivery.

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