Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Andersson, Olle; Rydén, Anna; Ruth, Magnus; Möller, Riitta; Finizia, Caterina

doi:10.3109/00365520903453166

Cited by 25 publications

(52 citation statements)

References 19 publications

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“…Definite and objective diagnostic method has not been developed except double-probe 24-h pH monitoring and RSI or RFS was used to diagnose LPRD and evaluate the treatment results. Some questionnaire was newly developed [13,14], but RSI and RFS can be widely used. Therefore, we used these two methods in this study.…”

Section: Discussionmentioning

confidence: 99%

Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease

Lee

Choi

Son

et al. 2011

Eur Arch Otorhinolaryngol

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The role of proton pump inhibitor in the treatment of laryngopharygneal reflux disease (LPRD) has been advocated, but there has been few reports dealing with large population based on time-related efficacy of rabeprazole. It was designed to assess the efficacy of rabeprazole and to evaluate which symptoms or findings varied significantly as medication sustained. Multiorgan, open-label cohort, prospective observational study was designed. We identified 1,142 patients with LPRD, and enrolled 455 patients, who participated fully in this survey and follow-up observation for 12 weeks. Reflux symptom index (RSI) and reflux finding score (RFS) were used to evaluate therapeutic efficacy. These parameters were evaluated at the 4th, 8th, and 12th weeks, respectively. Valid rate was used to explain improved proportion of patients after medication. The most common symptom was a globus sense in the throat. Posterior commissure hypertrophy was the most frequently encountered laryngoscopic finding. Female patients complained of heartburn and chest pain more than did male patients (P < 0.001), whereas male patients showed ventricular obliteration and erythematous changes more frequently than did female patients (P < 0.001). By RSI evaluation, scores gradually declined. Each item of the RSI improved at every visit (P < 0.001). Total RFS decreased progressively for 12 weeks and similar results were seen when every RFS item was individually examined. The proportion of patients who showed RSI and RFS falling by more than 50% after medication increased gradually as follow-up continued. This trend seemed to be significant (P < 0.001). Side effects of therapy were minimal. Despite the some constraints of an observational study, rabeprazole appeared to improve LPRD symptoms and signs. Prolonged medication at least 3 months may be beneficial to LPRD patients. Long-term medication effects require further evaluation.

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Section: Discussionmentioning

confidence: 99%

Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease

Lee

Choi

Son

et al. 2011

Eur Arch Otorhinolaryngol

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“…Four instruments met at least one criterion from each of the seven domains (RSI, Pharyngeal Reflux Symptom Questionnaire [PRSQ], GETS, and Supraesophageal Reflux Questionnaire [SERQ]). 18,21–23 , Of available measures, the PRSQ met the most criteria (16/18) followed by the RSI (13/18) and LPR-HRQL (13/18). None met all assessed criteria.…”

Section: Resultsmentioning

confidence: 99%

“…23,24 Question content for the remainder was based solely on the opinion of content experts (e.g., otolaryngologists, laryngologists, gastroenterologists, speech-language pathologists) who care for and study this population. In fact, content experts were ubiquitously involved in questionnaire content development.…”

Section: Resultsmentioning

confidence: 99%

Patient‐Reported Outcome Measures Related to Laryngopharyngeal Reflux

Francis¹,

Patel

Sharda

et al. 2016

Otolaryngol.--head neck surg.

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Objectives Patient-reported outcome (PRO) measures are often used to diagnose LPR and monitor treatment outcomes in clinical and research settings. The present systematic review was designed to identify currently available LPR-related PRO measures and to evaluate each measure’s instrument development, validation, and applicability. Data Sources MEDLINE via PubMed interface, Cumulative Index of Nursing and Allied Health Literature, and Health and Psychosocial Instrument databases were searched using relevant vocabulary and key terms related to PRO measures and LPR. Review Methods Three investigators independently performed abstract review, full-text review, and applied a previously developed checklist to critically assess measurement properties of each study meeting inclusion criteria. Results Of 4,947 studies reviewed, seven LPR-related PRO measures (publication year 1991 – 2010) met criteria for extraction and analysis. Two focused on globus and throat symptoms. Remaining measures were designed to assess LPR symptoms and monitor treatment outcomes in patients. None met all checklist criteria. Only 2/7 used patient input to devise item content and 2/7 assessed responsiveness to change. Thematic deficiencies in current LPR-related measures are inadequately demonstrated: content validity, construct validity, plan for interpretation, and literacy level assessment. Conclusion Laryngopharyngeal reflux is often diagnosed based on symptoms. Currently available LPR-related PRO measures used to symptomatically identify suspected LPR patients have disparate developmental rigor and important methodological deficiencies. Care should be exercised to understand the measurement characteristics and contextual relevance before applying these PRO measures for clinical, research, or quality initiatives.

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“…Allerdings muss berücksichtigt werden, dass ähnliche Symptome, wie sie [10,20]. Weiterentwicklungen dieses Fragebogens, wie beispielsweise der "Pharyngeale-Reflux-Symptom-Fragebogen" spielen heute in der klinischen Routine noch keine Rolle [1]. Mit dem "reflux finding score" (RFS) wird der endoskopische Befund beurteilt.…”

Section: Fragebogenunclassified

Möglichkeiten der Refluxdiagnostik durch den Hals-Nasen-Ohren-Arzt

Jecker¹

2012

HNO

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Reflux disease has gained in importance over the last decade since we know that many of the symptoms and diseases of the upper aerodigestive tract might be associated with reflux. However, a distinction needs to be made between extraesophageal reflux (EER) and gastroesophageal reflux disease (GERD). There are several techniques available for the diagnosis of EER. Furthermore, there are various pH monitoring devices to determine acid contamination of the larynx and the pharynx. In addition, flexible transnasal esophagoscopy is a practicable technique for the rapid examination of reflux, its cause as well as the diagnosis of reflux-induced mucosal changes in the esophagus. The present article describes the instruments used for the diagnosis of reflux against the background of our own experience and the international literature.

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Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Abstract: The PRSQ showed good psychometric properties and may become a valuable instrument for assessing LPR disease.

Cited by 25 publications

References 19 publications

Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease

Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease

Patient‐Reported Outcome Measures Related to Laryngopharyngeal Reflux

Möglichkeiten der Refluxdiagnostik durch den Hals-Nasen-Ohren-Arzt

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