Development and validation of a patient‐based disease activity score in rheumatoid arthritis that can be used in clinical trials and routine practice

Abstract

Objective. Assessor-based disease activity measures such as the Disease Activity Score in 28 joints (DAS28), although widely used in rheumatoid arthritis (RA), have high interobserver variability. We developed and validated a patientbased disease activity score (PDAS) as an alternative assessment.

Comparative quality of life in patients with depression and rheumatoid arthritis

“…(Choy et al, 2008a;Choy, Khoshaba, Cooper, MacGregor, & Scott, 2008b;Graves, Scott, Lempp, & Weinman, 2009;Kendrick et al, 2009). Participants in each study had not been assessed for co-morbidities such as depression among patients with RA, or for RA among the patients with depression.…”

Upswings in Cheerful Mood and Disease Activity in Patients with Rheumatoid Arthritis

“…We assessed patients' self-reported disease activity state with the Disease Activity Score-28 (DAS-28) [12]. The clinical assessment of disease activity was based on blood levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR).…”

Development and initial validation of composite parent‐ and child‐centered disease assessment indices for juvenile idiopathic arthritis

“…The JAPAI and JACAI were devised by a panel of 8 pediatric rheumatologists (AC, NR, BL, NS, SP, GCV, AM, AR) with 3 to Ͼ20 years of clinical experience in the field, who reached consensus on the individual measures to be included in the indices. Investigators were asked to base their choice on their clinical experience and on a review of the literature on PCROs in JIA (3-6) and patient-centered composite scores in adult rheumatoid arthritis (7)(8)(9)(10)(11)(12). After extensive discussion, all investigators agreed that both scores should include the following 4 items: 1) parent/child rating of overall well-being, 2) parent/child rating of pain intensity, 3) assessment of physical function, and 4) assessment of HRQOL.…”

“…Incorporation of these measures in patient assessment is deemed important because they reflect the parents' and children's perception of the disease course and the effectiveness of therapeutic interventions. Recently, composite disease activity scores entirely based on patient-reported outcomes have been developed for adult rheumatoid arthritis (7)(8)(9)(10)(11)(12). These measures have been found to be of value both in standard clinical care and as trial end points.…”