Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer

Cheng, Hua; Zhuang, Zhi Cheng; Wu, Yong; Zhang, Yi Yi; Liu, Xing; Zhuang, Jin Fu; Yang, Yuan; Gao, Yuan; Chen, Bin; Guan, Guo xian

doi:10.17305/bjbms.2020.5617

Cited by 55 publications

(52 citation statements)

References 34 publications

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“…The lack of reliable markers for early tumor diagnosis is still one of the key factors in the dismal prognosis of individuals with advanced STAD. Recent ndings have revealed that ferroptosis-related lncRNAs can act as prognostic targets in diverse cancers (13,14). Thus, we further con rmed the possible predictive value of ferroptosis-related lncRNAs in individuals with STAD.…”

Section: Prognostic Value Of Ferroptosis-related Lncrnas In Stadsupporting

confidence: 58%

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Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Wang¹,

Sun²,

Wang³

et al. 2021

Preprint

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Background: Ferroptosis is a form of cell death involved in diverse physiological context. Increasing evidence suggests that there is a closely regulatory relationship between ferroptosis and long noncoding RNAs (lncRNAs).Method: RNA-sequencing data from The Cancer Genome Atlas (TCGA) data resource and ferroptosis-related genes from FerrDb (http://www.zhounan.org/ferrdb/) data resource were employed to select differentially expressed lncRNAs. We performed Univariate Cox regression and multivariate Cox analyses analysis on these differentially expressed lncRNAs to screen independent predictive factors. Subsequently, we established two signatures for predicting overall survival (OS) and progression-free survival (PFS). Finally, experiments were conducted to verify the roles of LASTR in gastric cancer (GC).Results: We identified 12 differentially expressed lncRNAs linked with OS and 13 associated with PFS. Kaplan-Meier(K-M) analyses exhibited that the high-risk group was related to a poor prognosis of stomach adenocarcinoma (STAD). The AUCs of the OS, as well as PFS signatures of lncRNAs were 0.734 and 0.771, respectively, indicating their excellent efficacy in predicting STAD prognosis. Our experimental results illustrated that the inhibition of LASTR inhibited tumor proliferation and migration in GC.Conclusion: This comprehensive evaluation of the ferroptosis-related lncRNA landscape in STAD unearthed novel lncRNAs related to carcinogenesis. In addition, we also experimentally confirmed the effects of LASTR on proliferation, migration and ferroptosis. These results provide potential novel targets for tumor treatment and promote personalized medicine.

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Section: Prognostic Value Of Ferroptosis-related Lncrnas In Stadsupporting

confidence: 58%

“…The enrichment analyses indicated that ferroptosis-related lncRNAs are closely related to iron metabolism and could mediate some pivotal signaling pathways in tumorigenesis of STAD. (13,14). Thus, we further con rmed the possible predictive value of ferroptosis-related lncRNAs in individuals with STAD.…”

Section: Patient Characteristicssupporting

confidence: 52%

Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Wang¹,

Sun²,

Wang³

et al. 2021

Preprint

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“… 39 Ferroptosis has been investigated in a variety of cancers. For example, an LncRNA prognosis model, which was related to ferroptosis, was developed in colon cancer; 40 The genes related to ferroptosis were potentially prognostic molecular markers for patients with colorectal cancer; 41 Moreover, ferroptotic damage promotes tumorigenesis in pancreatic cancer patients; 42 A model of liver cancer patients was constructed, and it was based on four ferroptosis-related genes. This model predicted the prognosis of patients with liver cancer; 43 Studies have also been conducted to understand the correlation between ferroptosis and breast cancer patients, head and neck squamous cell carcinoma, and renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in lung adenocarcinoma

et al. 2021

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Recently, several molecular subtypes with different prognosis have been found in lung adenocarcinoma (LUAD). However, the characteristics of the ferroptosis molecular subtypes and the associated tumor microenvironment (TME) cell infiltration have not been fully studied in LUAD. Using 1160 lung adenocarcinoma samples, we explored the molecular subtypes mediated by ferroptosis-related genes, along with the associated TME cell infiltration. The ferroptosis score was constructed using the least absolute shrinkage and selection operator regression (LASSO) method to quantify the ferroptosis characteristics of a single tumor. Three different molecular subtypes related to ferroptosis, with different prognoses, were identified in LUAD. Analysis of TME cell infiltration revealed immune heterogeneity among the three subtypes. Cluster A was characterized by immunosuppression and was associated with stromal activation. Cluster C was characterized by a large number of immune cells infiltrating the TME, promoting tumor immune response, and it was significantly enriched in immune activation-related signaling pathways. Relatively less infiltration of immune cells was a feature of cluster B. The ferroptosis score can predict tumor subtype, immunity and prognosis. A low ferroptosis score was characterized by immune activation and good prognosis, as seen in the cluster C subtype. Relative immunosuppression and poor prognosis were the characteristics of a high ferroptosis score, as seen in cluster A and B subtypes. At the same time, the anti-PD-1/L1 immunotherapy cohort demonstrated that a low ferroptosis score was associated with higher efficacy of immunotherapy. The ferroptosis score is a promising biomarker that could be of great significance to determine the prognosis, molecular subtypes, TME cell infiltration characteristics and immunotherapy effects in patients with LUAD.

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“…What is more, LINC00662 is also closely related to gastric cancer, glioma, chordoma, and so on ( Liu et al, 2018a ; Wu et al, 2020b ; Wang et al, 2020 ). The remaining lncRNAs in the 8-lncRNA signature were associated with lung adenocarcinoma, colon cancer, and so on ( Liu et al, 2018b ; Cai et al, 2021 ). The research directed at the lncRNA in the multi-lncRNA signatures of ESCC and EAC was still deficient.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Immune-Related Multi-IncRNA Signatures Associated With Tumor Microenvironment in Esophageal Cancer

Pang

Yang

et al. 2021

Front. Genet.

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Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer death worldwide. Hence, for a better understanding of tumor microenvironment and to seek for novel molecular targets for esophageal cancer, we performed related studies on two histopathological subtypes of esophageal cancer: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Bioinformatic analyses were conducted based on the RNA-seq, genomic mutation, and clinical data from TCGA and GEO cohorts. We clustered patients into high-immunity and low-immunity groups through the ssGSEA results. The ESTIMATE algorithm was used to evaluate the tumor microenvironment. Patients with high immunity in both ESCC and EAC had lower tumor purity and poor survival. Subsequently, CIBERSORT was performed to learn about the detailed difference of tumor-infiltrating lymphocytes (TILs) between high- and low-immunity patients. Specific increase of M2 macrophages and decrease of activated dendric cells can be observed in ESCC and EAC, respectively. The most enriched functions and pathways of high-immunity patients were immunoglobulin complex, MHC class II protein complex, and allograft rejection according to the GO terms and KEGG. Two prognostic immune-related multi-lncRNA risk models were constructed and validated by ROC curve and PCA in ESCC and EAC. High-risk patients in both subtypes had poor survival, advanced clinical characteristics, and higher drug susceptibility except cisplatin and sorafenib. In addition, the tumor mutation burden (TMB) was positively correlated with the risk level in the ESCC and EAC and showed distinct differences between the two subtypes. In summary, we comprehensively analyzed the tumor microenvironment for two subtypes of esophageal cancer, identified two multi-lncRNA signatures predictive for the prognosis, and explored the possibility of the signatures to forecast drug susceptibility as well as TMB for the first time. The findings may serve as a conceptual basis for innovative strategy of individualized immunotherapy for esophageal cancer.

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Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer

Cited by 55 publications

References 34 publications

Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in lung adenocarcinoma

Prognostic Value of Immune-Related Multi-IncRNA Signatures Associated With Tumor Microenvironment in Esophageal Cancer

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