Development and validation of an LC–MS/MS method for quantitative determination of GS87, a novel antineoplastic agent, in mouse plasma

Kunati, Sandeep R.; Yang, Shuming; Wald, David N.; Xu, Yan

doi:10.1016/j.jpba.2018.02.034

Journal of Pharmaceutical and Biomedical Analysis

2018

DOI: 10.1016/j.jpba.2018.02.034

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Development and validation of an LC–MS/MS method for quantitative determination of GS87, a novel antineoplastic agent, in mouse plasma

Sandeep R. Kunati

Shuming Yang

David N. Wald

et al.

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2020

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Mastication Process of Natural Rubber/Butadiene Rubber Blending: Validation Method on Influence of Peptizer

Arti¹,

Hidayat²,

Ulfah³

et al. 2020

Macromolecular Symposia

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The performance of tire tread is measured by the combination of “magic triangle properties.” They are rolling resistance, traction, and wear. To obtain high quality of tire tread, good quality of rubber compound is necessary to be prepared. Natural rubber (NR) has a wide application especially in tire tread. Cured Butadiene Rubber (BR) impacts excellent abrasion resistance and low rolling resistance due to its low glass transition temperature (Tg). Mastication process is a very important step in compounding preparation. To obtain homogeneous compounding, mastication has to be prepared well. Recently, the effect of peptizer in the mastication process of natural rubber/butadiene rubber has been investigated by using Vestenamer, Aktiplast 8, and Rhenosin 145. To validate to method and formulation, the experiment is repeated three times to find out the type of peptizer that provide the highest compatibility to masticate natural rubber and butadiene rubber as well. The experimental design is done to collect the data and repeatability of each peptizer effect is analyzed by calculating the variance (ANOVA test). As expected, the addition of Vestenamer significantly increases the mechanical properties, and it has better repeatability than others. However, the value of tensile strength and tear strength are still lower than Aktiplast, but it has already fulfilled the requirement, 20 N/mm2 and 200 N, for tensile strength and tear strength, respectively. It is proved that Vestenamer can optimize the mastication process.

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Mastication Process of Natural Rubber/Butadiene Rubber Blending: Validation Method on Influence of Peptizer

Arti¹,

Hidayat²,

Ulfah³

et al. 2020

Macromolecular Symposia

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Development and validation of an LC–MS/MS method for quantitative determination of GS87, a novel antineoplastic agent, in mouse plasma

Cited by 1 publication

References 18 publications

Mastication Process of Natural Rubber/Butadiene Rubber Blending: Validation Method on Influence of Peptizer

Mastication Process of Natural Rubber/Butadiene Rubber Blending: Validation Method on Influence of Peptizer

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