Development and validation of an endoscopic activity score for canine inflammatory bowel disease

Slovak, Jennifer E.; Wang, C.; Sun, Yuzhi; Otoni, Cristiane C.; Morrison, Jo Ann; Deitz, Krysta L.; LeVine, Dana N.; Jergens, Albert E.

doi:10.1016/j.tvjl.2014.12.030

Cited by 37 publications

(46 citation statements)

References 25 publications

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“…Endoscopic scores were retrospectively evaluated by using still images based on the previously described simple endoscopic scoring system in which the absence (score 0) or presence (score 1) of friability, granularity, erosions, and lymphatic dilatation of the duodenum was assessed . These images were evaluated by an experienced endoscopist, and scores were summarized with maximum scores of 4.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Nagata

Ohta

Yokoyama

et al. 2020

Veterinary Internal Medicne

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Background In dogs with protein‐losing enteropathy (PLE), data on the clinical characteristics of food‐responsive PLE (FR‐PLE) remain scarce. Objective To determine the clinical characteristics of FR‐PLE in dogs responsive to ultralow‐fat diet (ULFD) management. Animals Thirty‐three dogs diagnosed with PLE based on standard diagnostic criteria. Methods Retrospective review of medical records. Clinical findings were compared between dogs with FR‐PLE (FR‐PLE group) and those with immunosuppressant‐responsive PLE (IR‐PLE) or nonresponsive PLE (NR‐PLE) (IR/NR‐PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR‐PLE and IR/NR‐PLE groups. Survival time was compared between the FR‐PLE and IR/NR‐PLE groups. Results Twenty‐three dogs responded to ULFD management and were diagnosed with FR‐PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR‐PLE group than in the IR/NR‐PLE group (P < .001). The AUC of CCECAI for differentiating the FR‐PLE group was 0.935 (95% confidence interval [CI], 0.845‐1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR‐PLE group (median, not reached) than in the IR/NR‐PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance Dogs that respond to ULFD management and are diagnosed with FR‐PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR‐PLE from IR‐PLE or NR‐PLE.

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Section: Methodsmentioning

confidence: 99%

Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Nagata

Ohta

Yokoyama

et al. 2020

Veterinary Internal Medicne

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“…This data could show the immune mediated basis of the disease and hypersensitivity reactions in the pathogenesis. In addition, it could explain the mode of action of immunomodulant drugs in the treatment (Slovak et al, 2014).…”

Section: Pathogenesismentioning

confidence: 99%

“…GI endoscopy is an easy, relatively non-invasive and useful method for determination the active inflammation. The criteria have been developed for qualitative evaluation of endoscopic mucosal appearances Table 3 (Slovak et al, 2014). In addition, his to pathological analysis is another method for the diagnosis of IBD and objective criteria are established in dogs Table 4 (Poullis et al, 2002;McCann et al, 2007;Magro et al, 2013).…”

Section: Diagnosismentioning

confidence: 99%

Inflammatory Bowel Disease and Current Treatment Options in Dogs

Arslan¹

2017

American Journal of Animal and Veterinary Sciences

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Inflammatory Bowel Disease (IBD) is an idiopathic and chronic gastrointestinal failure of cats, dogs and some farm animals such as horses. Since the long and difficult classical therapy of the disease has various side effects such as malignancy and lymphoma, new therapeutic methods are needed. However, a safe and standardized treatment protocol has not been developed, yet. Therefore, IBD treatment is still a big dilemma for both veterinary and human medicine. In this review, IBD and new possible therapeutic alternatives were evaluated for dogs.

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“…Endoscopy is used routinely to visualize the gastrointestinal mucosa and procure biopsy specimens from dogs and cats with a chronic history of gastrointestinal disease . Performance of ileoscopy is increasingly common because of discrepancies between duodenal and ileal histopathologic results .…”

Section: Introductionmentioning

confidence: 99%

“…Endoscopy is used routinely to visualize the gastrointestinal mucosa and procure biopsy specimens from dogs and cats with a chronic history of gastrointestinal disease. 1 Performance of ileoscopy is increasingly common because of discrepancies between duodenal and ileal histopathologic results. [2][3][4][5] Despite the increased frequency with which lower gastrointestinal endoscopy is performed, neither ileal nor cecal perforations have been reported, and none of the 4 reported colonic perforations occurred near the ileocecocolonic (ICC) valve.…”

Section: Introductionmentioning

confidence: 99%

Multicenter retrospective evaluation of ileocecocolic perforations associated with diagnostic lower gastrointestinal endoscopy in dogs and cats

Woolhead

Whittemore

Stewart

2020

Veterinary Internal Medicne

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Background Ileoscopy is increasingly performed in dogs and cats with gastrointestinal signs, but iatrogenic ileocecocolic (ICC) perforations have not been described. Hypothesis/Objectives To characterize endoscopic ICC perforations in dogs and cats. Animals Thirteen dogs and 2 cats. Methods This is a retrospective case series. Signalment, presentation, endoscopic equipment, colonic preparation, endoscopist's experience level, ileal intubation technique, method of diagnosis, perforation location, histopathology, management, and outcome data were collected and reviewed. Results Six ileal, 5 cecal, and 4 colonic perforations were identified between 2012 and 2019. Dogs weighed 2.4‐26 kg (median, 10.3 kg) and cats 4.6‐5.1 kg (median, 4.9 kg). Endoscopy was performed in dogs presented for vomiting (n = 4), as well as large (n = 5), mixed (n = 4), and small (n = 1) bowel diarrhea. Cats had large bowel diarrhea. Endoscopists included 1 supervised intern, 9 supervised internal medicine residents (2 first year, 6 second year, 1 third year), and 5 internal medicine diplomates. Diagnosis was delayed in 5 dogs, occurring 1‐5 days after endoscopy (median, 3 days); dogs were presented again with inappetence (n = 4), lethargy (n = 4), abdominal pain (n = 3), retching (n = 2), and syncope (n = 1). All animals underwent surgical correction. Histopathology did not identify lesions at the perforation site in any animal. Two dogs required a second surgery; 1 died 12 hours after surgery. Survival to discharge was 93%, with 78% surviving ≥8 months. Conclusions and Clinical Importance Iatrogenic endoscopic ICC perforation is not indicative of underlying disease and is associated with a good prognosis. Delayed diagnosis can occur. Therefore, perforation should be considered in the differential diagnosis for animals with clinical deterioration after endoscopy.

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Development and validation of an endoscopic activity score for canine inflammatory bowel disease

Cited by 37 publications

References 25 publications

Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Inflammatory Bowel Disease and Current Treatment Options in Dogs

Multicenter retrospective evaluation of ileocecocolic perforations associated with diagnostic lower gastrointestinal endoscopy in dogs and cats

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