Development and Validation of Atazanavir and Ritonavir Determination in Human Plasma by HPLC-MS Method

Komarov, T. N.; Шохин, И. Е.; Мискив, О. А.; Богданова, Д. С.; Алешина, А. В.; Медведев, Ю. В.; Bagaeva, N. S.

doi:10.33380/2305-2066-2020-9-1-99-108

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…It is most informative for severe ischemia (infarction), but not very effective at the early stages of the disease and in non-occlusive forms. The sensitivity and accuracy of laparoscopy in the diagnosis of mesenteric thrombosis are up to 90% [16], [17].…”

Section: One Of the Main Reasons For The Development Of Mesenteric Embolism Is Diseases With A Risk Ofmentioning

confidence: 99%

Mesenteric Vessel Thrombosis Treatment Experience

Белобородов

Vorobev

Sokolova

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: One of the most serious diseases among all emergency abdominal pathology is an acute violation of the mesenteric blood circulation. The rapid development of intestinal ischemia results in its infarction and necrosis. AIM: The study aims to assess the survival rate of patients with mesenteric vascular thrombosis, taking into account, the predictor characteristics influence of disease development factors. METHODS: The study presents a retrospective analysis of mesenteric vascular thrombosis clinical cases for 2016–2019. During this period, there were 147 patients with an established diagnosis at the Irkutsk Clinical Hospital No. 1, 21 of them met the study criteria. RESULTS: According to the type of thrombosis, there were two groups – occlusive (Group I, n = 11) and non occlusive (Group II, n = 10). Four patients (36.3%) of Group I and 7 patients (70%) of Group II (p = 0.388) recovered from the disease. Three patients (27.2%) of Group I and 4 patients (40%) of Group II (p = 0.662) received conservative therapy, 2 of them (66.6%) in Group I and 4 (100%) in Group II (p = 0.724) recovered from the disease. In addition, the authors performed a mortality assessment, according to the timing of the visit to a medical institution. Four (50%) out of eight patients who applied in the first 12 h, 2 (66%) out of three – in the first 12–24 h, and 5 (50%) out of 10 for more than 24 h of illness had a positive treatment result in the combined group. CONCLUSION: The patients over 70 years old with peritoneal symptoms and established intestinal necrosis have an extremely unfavorable prognosis. The primary mesenteric vessel thrombosis with additional contrast angiography still gives a moderate treatment prognosis.

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Section: One Of the Main Reasons For The Development Of Mesenteric Embolism Is Diseases With A Risk Ofmentioning

confidence: 99%

Mesenteric Vessel Thrombosis Treatment Experience

Белобородов

Vorobev

Sokolova

et al. 2021

Open Access Maced J Med Sci

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“…Frequently, challenges associated with the maintenance of patients having systemic HIV take roots in the aggressive behavior of fungal lesions [11]. If not treated in time, this particular infection is 70-100% lethal [9,[12][13][14][15]. This study aims to examine the frequency of invasive mycoses that were isolated from HIV-infected patients at urgent and planned admissions to a specialized hospital.…”

Section: Introductionmentioning

confidence: 99%

Visceral Mycoses as a Cause of Severe HIV Infection and Death

Азовцева

Viktorovа

2021

Int Arch Allergy Immunol

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Introduction: In recent years, there has been an increase in the number of systemic fungal infections among HIV-infected individuals. The article aimed to examine the frequency of invasive mycoses among the HIV-infected patients at the time of their urgent and/or planned admission to a specialized hospital. Methods: The diagnostic methods used in this study involved physical examination, laboratory testing, bacteriological examination, immunological examination, molecular genetic testing, and radiological imaging. The study was conducted under the ethical guidelines for retrospective studies and does not disclose data on individual patients. Results: Between 2016 and 2018, 85 HIV patients who died with HIV history underwent a series of clinical and pathomorphological examinations at the Novgorod Regional Infectious Diseases Hospital. Systemic mycoses frequently occur in the respiratory system and less often in the brain. Their incidence is severe and the mortality rates associated with it are high. In this study, PCP was the most common cause of death provoked by mycoses. Discussion/Conclusion: Systemic fungal disease can be diagnosed through a combination of diagnostic methods. A crucial factor in the reduction of mortality rates for systemic mycosis is the early diagnosis and intensive antimicrobial therapy.

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“…Dissatisfaction with the results of the standard anterior abdominal wall surgery makes surgeons seek ways to improve them not only by developing and implementing new methods but also by a using a differentiated approach to the choice of the surgery method. At the same time, the IVH surgical treatment should be minimally invasive and provide not only reconstruction of the anterior abdominal wall with maximum function recovery, but also reduction of the frequency of wound complications and hernia recurrences, while maintaining a high level of the quality of life of operated patients [ 20 21 22 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy Evaluation of a Case-Specific Approach for Surgical Treatment of Inicisional Ventral Hernia

Sokolova

Sherbatykh

Tolkachev

et al. 2021

International Journal of Surgery Protocols

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Background: The research aims to improve the surgical treatment results of incisional ventral hernia by applying a case-specific approach and a new method of anterior abdominal wall surgery. Materials and Methods: The paper reports the results of the prospective dynamic cohort study on 219 patients under 60 years of age, with small and medium hernias and up to 10 cm defects in the anterior abdominal wall (W1–W2), who underwent incisional ventral hernia treatment with mesh endoprostheses. Results: The paper offers a selection algorithm for anterior abdominal wall repair surgery and an original proprietary technique. We have developed and described in detail a new ‘extra-sublay’ technique of surgical intervention. The paper displays the frequency and pattern of complications, as well as the quality of life of patients after different prosthetic surgeries. In the main group, 65.0% of patients showed improvement, 88.4% showed long-term surgical success, 13.6% faced complications, and 4.5% experienced recurrence. Conclusion: After receiving the “on lay” treatment, 59.4% of patients showed positive results, 74.7% showed long-term surgical success, 40% had complications, and 3.1% experienced recurrence. After the “sub lay” intervention, 40.0% of patients demonstrated excellent results, 81.9% reached long-term success, 12% had complications, and 1.4% encountered recurrence. Highlights: The article shows a selection algorithm for anterior abdominal wall plastic repair method. One of the factors that cause relapses and ventral hernias themselves is obesity. The authors’ method of the VH surgical treatment has shown good results. Excellent indicators showed 65.0% of patients of the main group.

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Development and Validation of Atazanavir and Ritonavir Determination in Human Plasma by HPLC-MS Method

Cited by 5 publications

References 9 publications

Mesenteric Vessel Thrombosis Treatment Experience

Mesenteric Vessel Thrombosis Treatment Experience

Visceral Mycoses as a Cause of Severe HIV Infection and Death

Efficacy Evaluation of a Case-Specific Approach for Surgical Treatment of Inicisional Ventral Hernia

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