Development and Validation of Difference Spectrophotometric Method for the Quantitative Estimation of Mesalamine in Bulk Drug and Dosage forms.

Kumar, Praveen; Padmavathi, Yenumula; Niveditha, P; Babu, Nayaka Raghavendra

doi:10.5958/2231-5675.2017.00036.9

Cited by 9 publications

(1 citation statement)

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“…it is relatively insoluble in some organic solvents like ether and chloroform, while it is solubility increased in a diluted solution of bases and acids [2]. Some biological terms like enzymes are inhibited to be produced by MEZ, such as synthetase and cyclo-oxygenase [3]. also, MEZ played an important role as an activating factor of the platelet.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Saleem¹

2019

IHJPAS

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A spectrophotometric method is proposed for the determination of some drugs containing amino group such as mesalazine, metoclopramide and dopamine in pharmaceutical formulations. It was simple, precise, accurate, rapid, and based on the oxidation of each drug with chromate as an oxidizing agent in the presence of 1N hydrochloric acid. Then indigo carmine is reacted with residual chromate in the presence of a catalysis factor (sodium oxalate). Increasing in absorbance's value of the color system is proportional to the amount of the three drugs which is measured at the selected wavelength of 610 nm. The proposed method is obeying Beer's law in the ranges of (1-40, 2-44 and 2-52) ppm for the concentration of mesalazine, metoclopramide and dopamine respectively. Molar absorptivity was 0.191Ã—104, 0.449Ã—104 and 0.191Ã—104 L.mol-1.cm-1 mesalazine, metoclopramide and dopamine respectively. While, Sandell's sensitivity index of 0.0806, 0.0667 and 0.0806 Î¼g.cm-2 mesalazine, metoclopramide and dopamine respectively. The proposed spectrophotometric method has a good recovery when it is applied for the determination of the three drugs in pure form and pharmaceutical doses.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Saleem¹

2019

IHJPAS

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Oral-Genital Lichenoid Reaction: A Rare Hypersensitives to Drug, A Review

Gofur

Gofur²,

Gofur³

et al. 2022

RJPT

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Background: Lichenoid reaction as the result of hypersensitivity from drug might be had similir clinical appearance to idiopathic lichen planus. Lichenoid drug reaction is termed as a condition of the oral cavity having an identifiable etiology, which is clinically and histologically similar to oral lichen planus and also manifest on genital. A number of drugs have been described as a causative factor of those reactive lesions. Objectives : The aim of this study is to finding mechanism of oral-genital lichenoid reaction caused by drugs. Problem Statement: Potential Pathway of Oral-genital lichenoid reaction caused by drugs. Discussion: Oral lichenoid lesions could be impact from medication and contact antigenic reaction. Clinical condition these two look similar to oral lichen planus, also its pathology. Studies of LDR caused by angiotensin-converting enzyme (ACE) inhibitors, antimalaria, antituberculosis, antitumor and non-steroidal anti-inflammatory drugs (NSAIDs) have been found. Conclusion: OLR is a disease condition with definite identifiable aetiology. Cell-mediated immune dysregulation has been associated with pathogenesis, explaining oral and genital manifestation.

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Formulation, Characterization and In-vitro Evaluation of Prolonged Local Drug Delivery of Antimicrobial on Bone Tissue Formation

Sharma

Soundrapandian

Bhutia

2023

RJPT

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The present study aim to prepare and characterize prolonged local drug delivery of antimicrobial on bones tissue formation and its In-vitro evaluation. The results of drug released pattern were analysed after coating. In formulation (F1), the drug release was steep till 73%, where coating showed no such retardation effect. After 73% of drug release, F1 showed prolonged release of drug even after coating with 1% and 2% Chitosan, F2 and F3 showed prolonged better effect with 1% as compared to 2% Chitosan coating. In formulations containing one part of bioglass (F4 and F6) Showed prolonged release by 2% coating followed by 1% Chitosan coating. F5 was the exception where coating favoured dissolution. F8 and F9 showed prolonged release of drug by 1% than 2% Chitosan. In-case of In-vitro study, concentration was maintained above MIC i,e above 0.032 except in 816 hours where the drug concentration was observed below MIC (Fig No-14). F4C was found to be the best i,e 0.880 (Table No-06) for prolonged drug release over 6 weeks. FTIR study confirmed that characteristic peaks showed by Moxifloxicin (Fig No-3 & Table No-5) were 719cm-1, 1045cm-1, 1702cm-1 and 3327cm-1 which were also shown by developed formulations (725cm-1, 1051cm-1, 1703cm-1 and 3543cm-1). For In-vitro bioactivity, SEM were also performed after 24hrs (Fig No-15) and 48hrs (Fig No-16), the intensity of the HAP in 48hrs was more as compared to 24rs which confirmed that formulation is able to induced new bone cell after implantation. This result indicates that these newly prepared formulations could be a potential drug delivery system in osteomylietis condition (induces new bone cell) and can be helpful for the scientists for the particular field of study in near future.

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Development and Validation of Difference Spectrophotometric Method for the Quantitative Estimation of Mesalamine in Bulk Drug and Dosage forms.

Cited by 9 publications

References 0 publications

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Spectrophotometric Determination of some Drugs using Oxidation Reduction Reactions

Oral-Genital Lichenoid Reaction: A Rare Hypersensitives to Drug, A Review

Formulation, Characterization and In-vitro Evaluation of Prolonged Local Drug Delivery of Antimicrobial on Bone Tissue Formation

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