Development and Validation of New High Performance Thin Layer Chromatography Method for Determination of Aripiprazole in Bulk and Tablet Formulation

Deshmukh, Md. Faizan; Firke, Sandip D.; Khan, Md. Mujeeb G; Shirkhedkar, Atul A.; Surana, Sanjay J.

doi:10.1080/22297928.2019.1605926

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…This method was validated for linearity, accuracy, range, precision and robustness according to ICH Q2 (R1) guidelines. Another study of HPTLC was also prepared by M D Faizandde shmukh et al [38]. The details are enclosed in Table 5.…”

Section: Hptlcmentioning

confidence: 99%

A Compact Analytical Profile of Aripiprazole: Analytical Methodologies

Athira¹,

Rishad²,

Babu

et al. 2021

JPRI

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Aripiprazole (APZ) is an antipsychotic drug that belongs to benzisoxazole derivatives and is used to treat schizophrenia as well as acute manic or mixed effects in patients with bipolar 1 disorder. APZ is used to treat certain mental, mood disorders such as bipolar disorder, Schizophrenia, Tourette's syndrome, and irritability associated with autistic disorder. It may also be used in combination with other medication to treat depression. The present review article would be useful for prospective studies for researchers interested in APZ formulation production and quality management. Using a thorough computer assisted literature survey; this review touches upon the various reported analytical methods for the quantification of APZ both in API (Active Pharmaceutical Ingredient) and pharmaceutical dosage forms. The present write-up also encompasses the various published research articles like Spectroscopy techniques, X- Ray Diffraction (XRD), Electro Chemical Technique, Differential Scanning Calorimeter (DSC) and Capillary Electrophoresis. This is the first review article in this series with focus on the analytical profile of APZ. Although, several methods were reported in the literature, HPLC stands out first for the quantification of APZ.

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Section: Hptlcmentioning

confidence: 99%

A Compact Analytical Profile of Aripiprazole: Analytical Methodologies

Athira¹,

Rishad²,

Babu

et al. 2021

JPRI

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“…Aripiprazole (ARP) is a benzisoxazole antipsychotic drug of the sixth generation. According to a review of the literature, chromatographic methods [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], electrophoresis [ 16 ], and spectrophotometric methods [ 17 , 18 ] are among the few analytical techniques for detecting aripiprazole in drug formulations and biological materials.…”

Section: Introductionmentioning

confidence: 99%

Selective Spectrofluorimetric Approach for the Assessment of Two Antipsychotic Drugs through Derivatization with O-Phthalaldehyde

et al. 2022

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A facile and sensible spectrofluorimetric approach for the measurement of two antipsychotic medications, aripiperazole (ARP) and clozapine (CLZ), was devised and validated. The approach involves reacting the examined medicines with o-phthalaldehyde in the presence of β-mercaptoethanol in a borate buffer of pH 9.0 and pH 10 for ARP and CLZ, respectively, to produce a robustly fluorescent compound that is detected at 450 nm following excitation at 340 nm. The experimental variables influencing the performance and product stability were thoroughly investigated and optimized. Under optimal conditions, the intensity of the fluorescence was linear during a concentration range of 0.1–0.5 μg/mL, with a limit of detection (0.0391 and 0.0400 μg/mL) and limit of quantitation (0.1035 and 0.1332 μg/mL), respectively, for ARP and CLZ. The suggested approach was successful in analyzing commercialized tablets. A statistical investigation of the results produced by the suggested and standard methods showed no remarkable variation in the precision and accuracy of the two approaches. A chemical mechanism using o-phthalaldehyde was proposed.

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