Development and Validation of Stability Indicating RP-HPLC Method for the Determination of Process and Degradation-Related Impurities in Sugammadex Sodium Drug Substance

The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

“…The results obtained in our study showed superiority in terms of LOD, LOQ, and linear range compared to the studies. 4,5,7 Since the results obtained by mass spectroscopy are given as m / z , they could not be compared with our own results. 6,26,27…”

“…Analytical methods for the quantitative determination of sugammadex have been reported which include high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS), 4 ultraviolet-visible spectroscopy, 5 liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), 6 and reversed-phase (RP)-HPLC. 7 These chromatographic and spectroscopic methods have many advantages, such as monitoring one and multiple drugs simultaneously with high selectivity and sensitivity. However, the development of new analytical methods by using different techniques is always welcome especially if these methods are easier to apply, more accessible, cheaper, shorter, environmentally friendly, etc.…”