Development, characterization and in vitro–in vivo evaluation of Farnesol loaded niosomal gel for applications in oral candidiasis treatment

Barot, Tejas; Rawtani, Deepak; Kulkarni, Pratik

doi:10.1016/j.heliyon.2021.e07968

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…The ability of vesicles to retain medication was tested by storing the chosen niosomal suspension in sealed glass vials at 4 degrees C 2 degrees C, 25 degrees C 2 degrees C for 8 weeks. Periodically, samples were taken and examined for aggregation, drug entrapment, and residual drug content 16 .…”

Section: Tem Analysismentioning

confidence: 99%

Untitled

2024

IJPSR

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The main purpose of this current work is to optimize the formulation and in-vitro evaluation of gabapentin niosomes. Methods: Niosomes are formulated by utilizing the thin film method. Gabapentin niosomes are prepared with cholesterol and span 80. Pre-formulation and post-formulation studies were carried out for optimized gabapentin niosomes. Such as FTIR, DSC, Zeta, Particle size, TEM, SEM, and in-vitro drug release studies. Report: Gabapentin medication preformulation experiments were carried out. The ultraviolet spectroscopic maximum of gabapentin was found to be 206nm. Within the concentration range of 2-10 g/ml of drug in phosphate buffer 7.4 solutions; gabapentin follows Beers law with a slope of 0.1086 x and an R 2 value of 0.9985. The particle size was determined to be round and spherical in the improved formulation F7. The particle sizes are in the 50-120mm range. Particle's external morphology/outer surface morphology were determined. Conclusion: The goal of this study was to optimize the formulation and in-vitro evaluation of gabapentin niosomes for epilepsy treatment. As a result, the current research focuses on increasing drug permeability and encapsulating the drug in niosomes vesicles for long-term central nervous system drug delivery.

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Section: Tem Analysismentioning

confidence: 99%

Untitled

2024

IJPSR

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“…For instance, Barot et al designed and formulated a gel-based niosome loaded with farnesol to treat oral candidiasis caused by Candida albicans . The results revealed the biocompatibility, increased drug penetration, and antifungal activity of the proposed formulation [ 154 ].…”

Section: Niosome Nanocarriersmentioning

confidence: 99%

Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections

Barani,

Paknia,

Roostaee

et al. 2023

BioMed Research International

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Numerous disorders go untreated owing to a lack of a suitable drug delivery technology or an appropriate therapeutic moiety, particularly when toxicities and side effects are a major concern. Treatment options for microbiological infections are not fulfilled owing to significant adverse effects or extended therapeutic options. Advanced therapy options, such as active targeting, may be preferable to traditional ways of treating infectious diseases. Niosomes can be defined as microscopic lamellar molecules formed by a mixture of cholesterol, nonionic surfactants (alkyl or dialkyl polyglycerol ethers), and sometimes charge-inducing agents. These molecules comprise both hydrophilic and hydrophobic moieties of varying solubilities. In this review, several pathogenic microbes such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Plasmodium, Leishmania, and Candida spp. have been evaluated. Also, the development of a proper niosomal formulation for the required application was discussed. This review also reviews that an optimal formulation is dependent on several aspects, including the choice of nonionic surfactant, fabrication process, and fabrication parameters. Finally, this review will give information on the effectiveness of niosomes in treating acute microbial infections, the mechanism of action of niosomes in combating microbial pathogens, and the advantages of using niosomes over other treatment modalities.

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“…Zeta Potential Analysis: Surface charge of niosomes was determined by laser Doppler electrophoresis 29,30 .…”

Section: Surface and Shape Analysis By Temmentioning

confidence: 99%

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2023

IJPSR

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The present research work was to formulate optimize and evaluate hydrocortisone-loaded niosomal gel for the management of rheumatoid arthritis. Method: Niosomal gel was successfully prepared by lipid-thin film hydration process and optimized by using 2 3 full factorial designs using three independent variables (tween 80 concentration, cholesterol concentration, and sonication time) and three dependent variables (cumulative drug release, mean particle size and entrapment efficiency). The effect of all variables was assessed by response surface methodology. Results: The prepared formulations were evaluated in terms of particle size, in-vitro drug release, encapsulation efficiency, zeta potential, viscosity, and spreadability. Based on response surface methodology, S6 formulation was found to be the best formulation with entrapment efficiency of 92.27%, in-vitro drug release of 75.61% in 8 hrs, and mean particle diameter of 121.58 nm. The stability studies indicated that all the formulations are stable as none exhibited significant drug content change over time. Conclusion: The study indicated the successful development of hydrocortisone-loaded niosomal gels with improved penetration, good homogeneity, and enhancement of duration of action. It can thus be concluded that the developed gel could be an effective treatment for rheumatoid arthritis. INTRODUCTION:Hydrocortisone acetate belongs to the class of corticosteroids, which is a synthetic or semi-synthetic derivative of the natural hormone cortisol secreted by adrenal cortex 1, 2 . FDA approved it in 1952 for clinical use in managing inflammatory diseases like rheumatoid arthritis, psoriasis, asthma, eczema, and many more 3, 4 . The conventional therapy with hydrocortiosone is based on systemic delivery by different routes, which leads to serious complications 5-7 .

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Development, characterization and in vitro–in vivo evaluation of Farnesol loaded niosomal gel for applications in oral candidiasis treatment

Cited by 12 publications

References 53 publications

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Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections

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