Development, in vitro and in vivo evaluations of novel lipid drug delivery system of <i>Newbouldia laevis</i> (P. Beauv.)

Umeyor, Chukwuebuka; Anaka, Emmanuel; Kenechukwu, Franklin Chimaobi; Agbo, Chinazom Precious; Attama, Anthony A.

doi:10.1177/1849543516673445

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The DSC thermograms and the endothermic events of the main raw materials used to formulate the LNs, as well as the extract, are shown in Figure 8 . The results demonstrate that the melting enthalpy decreased sharply when comparing the primary lipid and the LNs [ 66 , 67 ]. This decrease in enthalpy indicates a decrease in the lipid matrix crystallinity, and it is commonly reported in works on the production of nanocarriers with crystalline structures, such as lipid nanoparticles [ 68 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Lipid Nanoparticles Containing Omega-3-Rich Extract of Microalga Nannochlorpsis gaditana

Blanco-Llamero

Galindo

Fonseca

et al. 2022

Foods

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Microalgae are described as a new source of a wide range of bioactive compounds with health-promoting properties, such as omega-3 lipids. This biomass product is gaining attention mainly due to its potential to accumulate different compounds depending on the species and environment, and it has been commonly recognized as a valuable nutraceutical alternative to fish and krill oils. In this work, we obtained the extract of the microalga Nannochloropsis gaditana, selected on the basis of its content of eicosapentaenoic acid (EPA) and glycolipids, which were determined using GC-MS and high-performance liquid chromatography (HPLC), respectively. To develop an oral formulation for the delivery of the extract, we used a 23 factorial design approach to obtain an optimal lipid nanoparticle formulation. The surfactant and solid lipid content were set as the independent variables, while the particle size, polydispersity index, and zeta potential were taken as the dependent variables of the design. To ensure the potential use of the optimum LN formulation to protect and modify the release of the loaded microalga extract, rheological and differential scanning calorimetry analyses were carried out. The developed formulations were found to be stable over 30 days, with an encapsulation efficiency over 60%.

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Section: Discussionmentioning

confidence: 99%

Development of Lipid Nanoparticles Containing Omega-3-Rich Extract of Microalga Nannochlorpsis gaditana

Blanco-Llamero

Galindo

Fonseca

et al. 2022

Foods

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Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery

Umeyor

Dan-Ejih

Okonkwo

et al. 2022

Braz. J. Pharm. Sci.

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The study is aimed at investigating the functional physicochemical and solid state characteristics of food-grade Tetracarpidium conophorum (T. conophorum) oil for possible application in the pharmaceutical industry for drug delivery. The oil was obtained by cold hexane extraction and its physicochemical properties including viscosity, pH, peroxide, acid, and thiobarbituric acid values, nutrient content, and fatty acid profile were determined. Admixtures of the oil with Softisan ® 154, a hydrogenated solid lipid from palm oil, were prepared to obtain matrices which were evaluated by differential scanning calorimetry, fourier-transform infrared spectroscopy, and x-ray diffractometry. Data from the study showed that T. conophorum oil had Newtonian flow behaviour, acidic pH, insignificant presence of hyperperoxides and malondialdehyde, contains minerals including calcium, magnesium, zinc, copper, manganese, iron, selenium, and potassium, vitamins including niacin (B3), thiamine (B1), cyanocobalamine (B12), ascorbic acid (C), and tocopherol (E), and long-chain saturated and unsaturated fatty acids including n-hexadecanoic acid, 9(Z)-octadecenoic acid, and cis-13-octadecenoic acid. The lipid matrices had low crystallinity and enthalpy values with increased amorphicity, and showed no destructive intermolecular interaction or incompatibility between T. conophorum oil and Softisan ® 154. In conclusion, the results have shown that, in addition to T. conophorum oil being useful as food, it will also be an important excipient for the development of novel, safe, and effective lipid-based drug delivery systems.

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Phytochemistry and Antibacterial Assessment of Ethyl acetate Leaf Extract of Newbouldia laevis

Bello

Suleiman

Idris

2023

UJMR

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A current trend in drug research is the desire to obtain novel antimicrobials with plant origins as an alternative therapy and a means to curb antimicrobial resistance. This study evaluated the phytochemistry and antibacterial activity of ethyl acetate leaf extract of Newbouldia laevis. The leaf of Newbouldia laevis was cold extracted with Ethyl acetate. The extract was evaluated for it phytochemical constituents using standard methods and antibacterial effect against some clinical bacterial isolates using well diffusion technique. The study revealed the presence of some phytochemicals, alkaloids, saponins, flavonoids, phenol, anthraquinones and steroids in the plant extract, which were believed to be a contributing factor to the observed antibacterial effects. The test isolates' susceptibility to the crude extract was measured at 25 mg/mL and 50 mg/mL, 75mg/mL and 100mg/mL. The growth inhibition of Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa ranges from 9.66±1.54 to 13.00±0.00, 10.00±1.00 to 11.00±1.00, 9.33±0.57 to 11.00±1.00, 14.00±0.00 to 17.33±1.52 and 9.33±0.57 to 10.66± 1.52 mm respectively. The Minimum Inhibitory Concentration was observed at 25mg/mL, 12.5mg/mL, 25mg/mL,12.5mg/mL and 25mg/mL against Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa respectively while the Minimum Bactericidal Concentrations was at 50mg/mL, 25mg/mL, 50mg/mL, 25mg/mL and 50mg/mL respectively. The observed antibacterial effects were believed to be due to the presence of alkaloids, saponins, flavonoids, phenol, anthraquinones and steroids detected in the extract. The results apparently justified the traditional use of this plant in treating bacterial infections whose causative agents are the organisms used in this study.

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Development, in vitro and in vivo evaluations of novel lipid drug delivery system of Newbouldia laevis (P. Beauv.)

Cited by 3 publications

References 23 publications

Development of Lipid Nanoparticles Containing Omega-3-Rich Extract of Microalga Nannochlorpsis gaditana

Development of Lipid Nanoparticles Containing Omega-3-Rich Extract of Microalga Nannochlorpsis gaditana

Profiling the physicochemical and solid state properties of edible Tetracarpidium conophorum oil and its admixtures for drug delivery

Phytochemistry and Antibacterial Assessment of Ethyl acetate Leaf Extract of Newbouldia laevis

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