“…Recently, we reported the development and preliminary evaluation of [ 18 F]LU14 ([ 18 F]5, Figure 2) and provided evidence for the brain-penetrant nature of this scaffold. 46 Compound [ 18 F]LU14 was developed based on a library of naphthyridine-2-one-carboxamides developed by Lucchesi and co-workers and further investigated by Pascali and co-workers. 47,48 Thus, in the present work, we report our efforts to develop a novel 18 F-labeled radioligand with improved binding affinity and metabolic stability by systematically modifying the structure of the literature-known naphthyrid-2one based CB2R ligands (compounds 5, 10, and 16).…”