Development of a 3D Brain PET Scanner Using CdTe Semiconductor Detectors and Its First Clinical Application

Morimoto, Yuichi; Ueno, Yuichiro; Takeuchi, Wataru; Kojima, Shinichi; Matsuzaki, Kei; Ishitsu, Takafumi; Umegaki, Kikuo; Kiyanagi, Yoshiaki; Kubo, Naoki; Katoh, Chietsugu; Shiga, Tohru; Shirato, Hiroki; Tamaki, Nagara

doi:10.1109/tns.2011.2146790

Cited by 38 publications

(42 citation statements)

References 25 publications

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“…To enable high-resolution imaging with a low amount of statistical data, we developed a reconstruction method that could suppress statistical noise without degrading the spatial resolution [1,10]. The method is based on maximum a posteriori (MAP) [11] with median root prior (MRP) [12] and uses a resolution recovery technique [13,14].…”

Section: Image Reconstruction Methodsmentioning

confidence: 99%

“…This scanner is described in detail in a previous report [1]. In brief, the scanner uses CdTe detectors for dedicated three-dimensional emission scanning.…”

Section: Outline Of Cdte-pet and Its Parameter Settingsmentioning

confidence: 99%

“…To improve sensitivity, a novel signal processing method was developed [1]. The effective atomic number of the CdTe is 50, so the whole absorption rate of the 511-keV gamma ray is smaller than the current scintillation detectors, and a considerable amount of scattered gamma rays are generated and absorbed in nearby detectors.…”

Section: Outline Of Cdte-pet and Its Parameter Settingsmentioning

confidence: 99%

“…In particular, in oncology, biological imaging by positron emission tomography (PET) permits not only tumor detection but also gross tumor delineation and identification of biological heterogeneities [1,2]. In the delineation of tumor boundaries by PET, achieving a good spatial resolution and quantitative accuracy are physical imaging concerns.…”

Section: Introductionmentioning

confidence: 99%

“…These features of semiconductor detectors may lead to improved PET and SPECT images. The authors previously developed CdTe semiconductor detector-based PET (CdTe-PET) [1,2] and SPECT (CdTe-SPECT) [6,7]. The physical and clinical performances of the systems were evaluated through phantom, animal, and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

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Semiconductor Detector-Based Scanners for Nuclear Medicine

Takeuchi

Suzuki

Ueno

et al. 2016

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

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Semiconductor detectors have the potential to improve the quantitative accuracy of nuclear medicine imaging with their better energy and intrinsic spatial resolutions than those of conventional scintillator-based detectors. The fine energy resolution leads to a better image contrast due to better scatter rejection. The fine intrinsic spatial resolution due to a pixelated structure leads to a better image contrast and lower partial volume effect. Their pixelated structures also improve the count-rate capability. The authors developed CdTe semiconductor detectorbased positron emission tomography (CdTe-PET) and single-photon emission computed tomography (CdTe-SPECT) in order to test the potential of using semiconductor detectors in nuclear medicine. The physical performances of both systems were measured in several phantom experiments. The capability of using CdTe-PET

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Section: Image Reconstruction Methodsmentioning

confidence: 99%

“…This scanner is described in detail in a previous report [1]. In brief, the scanner uses CdTe detectors for dedicated three-dimensional emission scanning.…”

Section: Outline Of Cdte-pet and Its Parameter Settingsmentioning

confidence: 99%

Section: Outline Of Cdte-pet and Its Parameter Settingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Semiconductor Detector-Based Scanners for Nuclear Medicine

Takeuchi

Suzuki

Ueno

et al. 2016

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

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High‐resolution and high‐sensitivity PET for quantitative molecular imaging of the monoaminergic nuclei: A GATE simulation study

et al. 2022

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Purpose Quantitative in vivo molecular imaging of fine brain structures requires high‐spatial resolution and high‐sensitivity. Positron emission tomography (PET) is an attractive candidate to introduce molecular imaging into standard clinical care due to its highly targeted and versatile imaging capabilities based on the radiotracer being used. However, PET suffers from relatively poor spatial resolution compared to other clinical imaging modalities, which limits its ability to accurately quantify radiotracer uptake in brain regions and nuclei smaller than 3 mm in diameter. Here we introduce a new practical and cost‐effective high‐resolution and high‐sensitivity brain‐dedicated PET scanner, using our depth‐encoding Prism‐PET detector modules arranged in a conformal decagon geometry, to substantially reduce the partial volume effect and enable accurate radiotracer uptake quantification in small subcortical nuclei. Methods Two Prism‐PET brain scanner setups were proposed based on our 4‐to‐1 and 9‐to‐1 coupling of scintillators to readout pixels using 1.5×1.5×20$1.5 \times 1.5 \times 20$ mm3 and 0.987×0.987×20$0.987 \times 0.987 \times 20$ mm3 crystal columns, respectively. Monte Carlo simulations of our Prism‐PET scanners, Siemens Biograph Vision, and United Imaging EXPLORER were performed using Geant4 application for tomographic emission (GATE). National Electrical Manufacturers Association (NEMA) standard was followed for the evaluation of spatial resolution, sensitivity, and count‐rate performance. An ultra‐micro hot spot phantom was simulated for assessing image quality. A modified Zubal brain phantom was utilized for radiotracer imaging simulations of 5‐HT1A receptors, which are abundant in the raphe nuclei (RN), and norepinephrine transporters, which are highly concentrated in the bilateral locus coeruleus (LC). Results The Prism‐PET brain scanner with 1.5 mm crystals is superior to that with 1 mm crystals as the former offers better depth‐of‐interaction (DOI) resolution, which is key to realizing compact and conformal PET scanner geometries. We achieved uniform 1.3 mm full‐width‐at‐half‐maximum (FWHM) spatial resolutions across the entire transaxial field‐of‐view (FOV), a NEMA sensitivity of 52.1 kcps/MBq, and a peak noise equivalent count rate (NECR) of 957.8 kcps at 25.2 kBq/mL using 450–650 keV energy window. Hot spot phantom results demonstrate that our scanner can resolve regions as small as 1.35 mm in diameter at both center and 10 cm away from the center of the transaixal FOV. Both 5‐HT1A receptor and norepinephrine transporter brain simulations prove that our Prism‐PET scanner enables accurate quantification of radiotracer uptake in small brain regions, with a 1.8‐fold and 2.6‐fold improvement in the dorsal RN as well as a 3.2‐fold and 4.4‐fold improvement in the bilateral LC compared to the Biograph Vision and EXPLORER, respectively. Conclusions Based on our simulation results, the proposed high‐resolution and high‐sensitivity Prism‐PET brain scanner is a promising cost‐effective candidate ...

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Medical Applications of II-VI Semiconductor-Based Radiation Detectors

Vatavu¹

2023

Handbook of II-VI Semiconductor-Based Sensors and Radiation Detectors

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Development of a 3D Brain PET Scanner Using CdTe Semiconductor Detectors and Its First Clinical Application

Cited by 38 publications

References 25 publications

Semiconductor Detector-Based Scanners for Nuclear Medicine

Semiconductor Detector-Based Scanners for Nuclear Medicine

High‐resolution and high‐sensitivity PET for quantitative molecular imaging of the monoaminergic nuclei: A GATE simulation study

Medical Applications of II-VI Semiconductor-Based Radiation Detectors

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