Development of a bioactive glass fiber reinforced starch–polycaprolactone composite

Jukola, H.; Nikkola, L.; Gomes, Manuela E.; Chiellini, Federica; Tukiainen, Mikko; Kellomäki, Minna; Chiellini, Emo; Reis, Rui L.; Ashammakhi, Nureddin

doi:10.1002/jbm.b.31093

Cited by 23 publications

(18 citation statements)

References 27 publications

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“…One major problem with bioactive glasses is their brittleness, that is, poor tensile strength. However, due to their high stiffness and compression strength, bioactive glasses have been used as reinforcing components in various composites with biocompatible polymers . In such a composite, ideally, the glass provides mechanical strength and bioactivity, while the polymer gives formability and flexibility.…”

Section: Introductionmentioning

confidence: 99%

“…However, due to their high stiffness and compression strength, bioactive glasses have been used as reinforcing components in various composites with biocompatible polymers. [3][4][5] In such a composite, ideally, the glass provides mechanical strength and bioactivity, while the polymer gives formability and flexibility. Bioactive glass may release ions, which influence the cellular processes or induce antibacterial effects when added to biopolymer tissue engineering scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Dissolution of Bioactive Glasses in Acidic Solutions with the Focus on Lactic Acid

Björkvik

Wang

Hupa

2016

Int J of Appl Glass Sci

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This work reports the dissolution of bioactive glasses in acidic solutions. The focus was on lactic acid, thus mimicking the conditions that may develop locally during in vivo degradation of polylactic acid/bioactive glass composites. First, the dissolution of glasses 45S5, S53P4, and S68 was studied in 1.2 M lactic acid. The leaching of ions from 45S5 in lactic acid solution was further compared with the reactions in hydrochloric acid solution. Finally, Tris-buffered solutions in which the pH was adjusted to 7.4 using hydrochloric or lactic acid were used to study the effect of the acidic components on the dissolution of 45S5. The dissolution extent followed the initial acid concentrations: greater in lactic acid and lower in hydrochloric acid of the same initial pH. Rapid, preferential dissolution of Na, Ca, and P took place in lactic acid solution, thus suggesting that locally high concentrations of degradation products of lactic acid may enhance the dissolution of bioactive glass in Polylactic acid composites. When solution pH exceeded 4, calcium phosphate started to form on the glass surface.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dissolution of Bioactive Glasses in Acidic Solutions with the Focus on Lactic Acid

Björkvik

Wang

Hupa

2016

Int J of Appl Glass Sci

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“…12 The reinforcements have been applied in the form of nanoparticles, submicron tubes, microspheres, nanofibres and microfibers. [8][9][10][11][12][13][14][15] Jukola et al 16 investigated bioactive glass (BAG 1-98) fibre reinforced PCL and showed that the initial shear strength increased from 16 MPa to 25 MPa after reinforcement with 13% (wt%) BAG, whilst the initial bending strength increased from 30 MPa to 50 MPa. A binary (50 mol% P 2 O 5 and 50 mol% CaO) phosphate glass fibre reinforced PCL composite studied by Ahmed et al 17 showed initial flexural modulus increase from 0.5 GPa (for PCL alone) to almost 1 GPa with fibre volume fraction (Vf) of 6.4%, and to approximately 2.4 GPa with fibre Vf of 18%.…”

Section: Introductionmentioning

confidence: 99%

Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

et al. 2014

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Retention of mechanical properties of phosphate glass fibre reinforced degradable polyesters such as polycaprolactone and polylactic acid in aqueous media has been shown to be strongly influenced by the integrity of the fibre/polymer interface. A previous study utilising 'single fibre' fragmentation tests found that coating with magnesium improved the fibre and matrix interfacial shear strength. Therefore, the aim of this study was to investigate the effects of a magnesium coating on the manufacture and characterisation of a random chopped fibre reinforced polycaprolactone composite. Short chopped strand non-woven phosphate glass fibre mats were sputter coated with degradable magnesium to manufacture phosphate glass fibre/polycaprolactone composites. The degradation behaviour (water uptake, mass loss and pH change of the media) of these polycaprolactone composites as well as of pure polycaprolactone was investigated in phosphate buffered saline. The Mg coated fibre reinforced composites revealed less water uptake and mass loss during degradation compared to the non-coated composites. The cations released were also explored and a lower ion release profile for all three cations investigated (namely Na(+), Mg(2+) and Ca(2+)) was seen for the Mg coated composite samples. An increase of 17% in tensile strength and 47% in tensile modulus was obtained for the Mg coated composite samples. Both flexural and tensile properties were investigated and a higher retention of mechanical properties was obtained for the Mg coated fibre reinforced composite samples up to 10 days immersion in PBS. Cytocompatibility study showed both composite samples (coated and non-coated) had good cytocompatibility with human osteosarcoma cell line.

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“…The present study allowed comparison of two selected hASC subpopulations previously studied (Rada et al , 2010) and to clarify the behaviour of these cells, particularly their in vivo and in vitro osteogenic differentiation potentials, when seeded into SPCL fibre‐mesh scaffolds, a well‐characterized 3D structure (Gomes et al , 2003, 2008; Fuchs et al , 2009a; da Silva et al , 2009; Jukola et al , 2008). In order to trace the eventual cell migration, the cells used for the experiments were transfected with GFP.…”

Section: Discussionmentioning

confidence: 91%

Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study

Rada¹,

Santos²,

Marques³

et al. 2011

J Tissue Eng Regen Med

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The first stem cells considered for the reconstruction of bone were bone marrow mesenchymal stem cells (BMSCs). Subsequently, cells with similar marker expression panel and differentiation potential were found in new sources of cells, such as adipose tissue. This source of stem cells has a promising future in tissue-engineering applications, considering the abundance of this tissue in the human body, the easy harvesting and the high number of stem cells that are available from such a small amount of tissue. The isolation of the adipose stem cells is generally performed by means of enzymatic digestion of the tissues, followed by a natural selection of the stem cells based on their capacity to adhere to the culture flasks, leading to a quite heterogeneous population. This constitutes a major drawback for the use of these cells, since the heterogeneity of the cell culture obtained can compromise their proliferation and differentiation potential. In the present study we have analysed the in vitro and in vivo behaviour of two selected subpopulations with high osteogenic potential. For this purpose, ASCs(CD29+) and ASCs (STRO-1+)subpopulations were isolated and in vitro cultured onto a biodegradable polymeric scaffold, using osteogenic medium, before implantation in a nude mice model. The biodegradable polymeric scaffold used is a fibre-mesh structure based on a blend of starch and polycaprolatone (SPCL) that has been successfully used in several bone tissue-engineering studies. The implanted ASCs-scaffold constructs promoted the formation of new bone tissue in nude mice. However, the results obtained show differences in the behaviour of the two ASCs subpopulations under study, particularly regarding their potential to differentiate into the osteogenic lineage, and allowed the indentification of ASCs (STRO-1+) as the best subpopulation for bone tissue-engineering applications.

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Development of a bioactive glass fiber reinforced starch–polycaprolactone composite

Cited by 23 publications

References 27 publications

Dissolution of Bioactive Glasses in Acidic Solutions with the Focus on Lactic Acid

Dissolution of Bioactive Glasses in Acidic Solutions with the Focus on Lactic Acid

Mechanical, degradation and cytocompatibility properties of magnesium coated phosphate glass fibre reinforced polycaprolactone composites

Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study

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