Development of a broad selective molecularly imprinted polymers-based solid phase extraction of contraceptive drug levonorgestrel from water samples

Qi, Xiaoling; Yang, Xiaoming; Wang, Bin; Yang, Hong; Deng, Anping

doi:10.1080/03067319.2010.533767

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…As a durable and highly specific SPE material, the molecularly impressed polymer (MIP) can overcome the aqueous matrix's influence to enrich ultratrace amounts of target compounds. It is possible to use MISPE to separate and enrich numerous pharmaceuticals from environmental water, such as herbicides [38], phenolic compounds [39], pesticides [40] and hormones [41]. It is more practical to prepare an MIP that can selectively enrich multiple structural analogs due to the multiple antibiotics in water samples.…”

Section: D) Mispe Application In Drugsmentioning

confidence: 99%

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Gopalan

Hasanah

2019

Int J App Pharm

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Solid Phase Extraction is a method used for extraction, purification of compounds contained in complex matrices and purification of samples in the fields of industry, pharmacy, and toxicology analysis. This review represents the recent advances of solid phase extraction from different mode of separation which are the most commonly used in recent days such as molecular imprinting solid phase extraction (MISPE), magnetic solid phase extraction (MSPE) and matrix solid phase dispersion (MSPD). In this review, the applications of MISPE in the analysis of agrochemicals such as herbicides, fungicides and insecticides are summarized. This review also states preparation of various magnetic composites (MSPE) based on graphene and its application as adsorbents in pre concentrating natural mixes, organic macromolecules. Besides this, this review summarizes the application of MSPD in biological, food, and environmental samples, including both organic and inorganic analyte.

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Section: D) Mispe Application In Drugsmentioning

confidence: 99%

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Gopalan

Hasanah

2019

Int J App Pharm

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show abstract

“…The molecularly imprinted polymer (MIP), as a durable and highly specific SPE material, can overcome the influence of the aqueous matrix to enrich ultra-trace amounts of target compounds. It is feasible to utilize molecularly imprinted solid phase extraction (MISPE) to separate and enrich numerous pharmaceuticals from environmental water, such as herbicides [ 18 ], phenolic compounds [ 19 ], pesticides [ 20 ], and hormones [ 21 ]. Nevertheless, only one compound (the template or its analog) was investigated in most of these studies.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

Song

Zhou

et al. 2018

Molecules

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With the extensive application of antibiotics in livestock, their contamination of the aquatic environment has received more attention. Molecularly imprinted polymer (MIP), as an eco-friendly and durable solid-phase extraction material, has shown great potential for the separation and enrichment of antibiotics in water. This study aims at developing a practical and economical method based on molecularly imprinted solid phase extraction (MISPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneously detecting ten macrolide drugs in different sources of water samples. The MIP was synthesized by bulk polymerization using tylosin as the template and methacrylic acid as the functional monomer. The MIP exhibited a favorable load-bearing capacity for water (>90 mL), which is more than triple that of non-molecularly imprinted polymers (NIP). The mean recoveries of macrolides at four spiked concentration levels (limit of quantification, 40, 100, and 400 ng/L) were 62.6–100.9%, with intra-day and inter-day relative standard deviations below 12.6%. The limit of detection and limit of quantification were 1.0–15.0 ng/L and 3.0–40.0 ng/L, respectively. Finally, the proposed method was successfully applied to the analysis of real water samples.

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“…The precision and accuracy of the method were satisfactory and it gave average recoveries between 89.1 and 91.0%. In a similar way, Qi et al [65], prepared a MIP by conventional bulk polymerization for the extraction of levonorgestrel from water samples. The synthesized MIPs not only displayed high specific recognition for levonorgestrel (recoveries > 79%), but also showed high cross-reactivity values for structurally related contraceptive drugs, suggesting that MIPs could be used as broad specific recognition absorbent.…”

Section: Compoundsmentioning

confidence: 99%

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

Lucci¹,

Pacetti²,

Núñez³

et al. 2012

Chromatography - The Most Versatile Method of Chemical Analysis

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Development of a broad selective molecularly imprinted polymers-based solid phase extraction of contraceptive drug levonorgestrel from water samples

Cited by 7 publications

References 30 publications

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Mi-Spe, M-Spe and M-SPD Recent Application on Solid Phase Extraction for Compound Extraction of Complex Matrices

Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

Current Trends in Sample Treatment Techniques for Environmental and Food Analysis

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