A systematic review and meta-analysis was conducted to estimate the pooled effect of influenza vaccinations for health workers (HWs). Nine databases were screened to identify randomized clinical trials and comparative observational studies that reported the effect of influenza vaccination among HWs. The risk ratio (RR), standardized mean difference, and 95% confidence interval (CI) were employed to study the effect size using fixed/random-effect models. Subgroup analyses and sensitivity analyses were conducted accordingly. Publication bias was examined. Sixteen studies (involving 7971 HWs from nine countries) were included after a comprehensive literature search. The combined RR regarding the incidence of laboratory-confirmed influenza was 0.36 (95% CI: 0.25 to 0.54), the incidence of influenza-like illness (ILI) was 0.69 (95% CI: 0.45 to 1.06), the absenteeism rate was 0.63 (95% CI: 0.46 to 0.86), and the integrated standardized mean difference of workdays lost was −0.18 (95% CI: −0.28 to −0.07) days/person. The subgroup analysis indicated that vaccination significantly decreases the incidence of laboratory-confirmed influenza in different countries, study populations, and average-age vaccinated groups. Influenza vaccinations could effectively reduce the incidence of laboratory-confirmed influenza, absenteeism rates, and workdays lost among HWs. It is advisable, therefore, to improve the coverage and increase the influenza vaccination count among HWs, which may benefit both workers and medical institutions.
Objectives
To observe effect of rosuvastatin on renal function in patients with mild or moderate renal disfunction and type 2 diabetes undergoing cardiovascular angiographic.
Methods
This study included 84 patients with mild or moderate renal disfunction and type 2 diabetes undergoing cardiovascular angiographic in wuhan asian heart hospital. The patiens were were randomised into rosuvastatin groups and control groups. The change of glomerular filtration rate (GFR) in the second or third postoperative day compared to baseline level were observed, and the change of urine albumin creatinine ratio (a/c) in postoperative 3 days compared to baseline level were also observed.
Results
The change of glomerular filtration rate from baseline in postoperative 2 days (ml/min): rosuvastatin groups (-0.017 ± 0.109) vs control groups (0.043 ± 0.112), P = 0.018. The change of glomerular filtration rate from baseline in postoperative 3 days (ml/min):rosuvastatin groups (-0.045 ± 0.1) vs control groups (0.002 ± 0.035), P = 0.035. The change of urine albumin creatinine ratio (a / c) (ug / ml) from baseline in postoperative 3 days: rosuvastatin groups (0.164 ± 2.254) vs control groups (-0.450 ± 0.966), P = 0.147.
Conclusions
Rosuvastatin may be slightly lower GFR in the second or third postoperative day in patients with mild or moderate renal insufficiency with type 2 diabetes undergoing cardiac angiography, but does not affect the urinary albumin creatinine ratio (a/ c) in the third postoperative day.
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