This paper presents the modeling and experimentation of a three degrees of freedom (3-DOF) piezo-actuated mechanism. The displacements of the piezoelectric stack actuators are amplified with lever mechanisms to achieve large displacement output. In order to accurately model the mechanism, a comprehensive model, which uses the transfer matrix method to describe the dynamics characteristics and the modified Bouc–Wen hysteresis operator to represent the hysteresis, is presented. Ultimately, the proposed comprehensive model of the mechanism is experimentally investigated for its performance. Experimental results show that the proposed comprehensive model can accurately portray the hysteresis and dynamics characteristics of the 3-DOF piezo-actuated mechanism.