Development of a compact and general-purpose experimental apparatus with a touch-sensitive screen for use in evaluating cognitive functions in common marmosets

Takemoto, Atsushi; Izumi, Akihiro; Miwa, Makiko; Nakamura, Katsuki

doi:10.1016/j.jneumeth.2011.04.029

Cited by 39 publications

(36 citation statements)

References 10 publications

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“…(17.8 cm) tablet computer and a USB-driven feeder that was used to present stimuli, record responses, and deliver rewards (Takemoto et al, 2011). The apparatus was attached to the cage during the experiment.…”

Section: Apparatusmentioning

confidence: 99%

Individual variability in visual discrimination and reversal learning performance in common marmosets

Takemoto

Miwa

Koba

et al. 2015

Neuroscience Research

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Section: Apparatusmentioning

confidence: 99%

Individual variability in visual discrimination and reversal learning performance in common marmosets

Takemoto

Miwa

Koba

et al. 2015

Neuroscience Research

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“…The presentation of stimuli, recording of responses, and delivery of rewards were all performed using a compact apparatus consisting of a 7 inch tablet computer and a USB-driven feeder65. The apparatus was attached to the cage in the isolator rack system during the experiment.…”

Section: Methodsmentioning

confidence: 99%

Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown

Takaji

Takemoto

Yokoyama³

et al. 2016

Sci Rep

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The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation exists between the caudate nucleus and putamen in primates. Here, we successfully decreased dopamine D1 receptor (D1R) or D2R mRNA expression levels selectively in the marmoset caudate using shRNA knockdown techniques, as determined using positron emission tomography imaging with specific D1R and D2R ligands and postmortem in situ hybridization analysis. We then conducted a voxel-based correlation analysis between binding potential values of PET imaging and visual discrimination learning task performance in these genetically modified marmosets to find a critical role for the caudate D2R but no apparent role for the caudate D1R. This latter finding challenges the current understanding of the mechanisms underlying D1R activation in the caudate.

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“…There have been several previous studies investigating complex behavior in the marmoset (e.g., Spinelli et al 2004; Takemoto et al 2011; 2015; Yamazaki et al 2014) and, in particular, reversal learning has been used to evaluate neurochemical signaling in the orbitofrontal cortex thought to mediate response inhibition, (e.g., Clarke et al 2004; 2011; Rygula et al 2010). The present studies, however, were designed expressly to characterize the development of discrimination learning and response inhibition by using, respectively, the repeated acquisition and discrimination reversal tasks in which subjects learned and reversed novel stimuli daily, rather than serial reversals of the same task (cf.…”

Section: Introductionmentioning

confidence: 99%

Touchscreen assays of learning, response inhibition, and motivation in the marmoset (Callithrix jacchus)

2016

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Recent developments in precision gene editing have led to the emergence of the marmoset as an experimental subject of considerable interest and translational value. A better understanding of behavioral phenotypes of the common marmoset will inform the extent to which forthcoming transgenic mutants are cognitively intact. Therefore, additional information regarding their learning, inhibitory control, and motivational abilities is needed. The present studies used touchscreen-based repeated acquisition and discrimination reversal tasks to examine basic dimensions of learning and response inhibition. Marmosets were trained daily to respond to one of two simultaneously presented novel stimuli. Subjects learned to discriminate the two stimuli (acquisition) and, subsequently, with the contingencies switched (reversal). In addition, progressive ratio performance was used to measure the effort expended to obtain a highly palatable reinforcer varying in magnitude and, thereby, provide an index of relative motivational value. Results indicate that rates of both acquisition and reversal of novel discriminations increased across successive sessions, but that rate of reversal learning remained slower than acquisition learning, i.e., more trials were needed for mastery. A positive correlation was observed between progressive ratio break point and reinforcement magnitude. These results closely replicate previous findings with squirrel monkeys, thus providing evidence of similarity in learning processes across nonhuman primate species. Moreover, these data provide key information about the normative phenotype of wild-type marmosets using three relevant behavioral endpoints.

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Development of a compact and general-purpose experimental apparatus with a touch-sensitive screen for use in evaluating cognitive functions in common marmosets

Cited by 39 publications

References 10 publications

Individual variability in visual discrimination and reversal learning performance in common marmosets

Individual variability in visual discrimination and reversal learning performance in common marmosets

Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown

Touchscreen assays of learning, response inhibition, and motivation in the marmoset (Callithrix jacchus)

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