Development of a computational simulation tool to design a protocol for treating prostate tumours using transurethral laser photothermal therapy

Manuchehrabadi, Navid; Zhu, Liang

doi:10.3109/02656736.2014.948497

Cited by 42 publications

(16 citation statements)

References 43 publications

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“…While intracellular temperature is necessary to explain the damage induced in the cell under treatment, the exact knowledge of the thermal gradient created in its surroundings is fundamental to explain the damage appearing in neighboring cells . The magnitude and extension of thermal gradients in the surrounding of cells and other heating objects in aqueous media have been estimated and postulated in the past, but neither has been experimentally measured …”

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confidence: 99%

Thermal Scanning at the Cellular Level by an Optically Trapped Upconverting Fluorescent Particle

et al. 2016

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in: Yb 3+ excitation provides thermal sensing during optical manipulation. Thus, three-dimensional particle scanning allows for the measurement of thermal gradients in the surroundings of individual cancer cells subjected to a plasmonic-mediated photothermal therapy. It is found that such thermal gradients extends for distances larger than 10 microns, avoiding real single cell photothermal treatments under in vitro conditions. This work introduces to the scientific community a novel and simple approach for high resolution thermal sensing at the cellular level that could constitute a powerful tool for a better understanding of cell dynamics during thermal treatments.

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confidence: 99%

Thermal Scanning at the Cellular Level by an Optically Trapped Upconverting Fluorescent Particle

et al. 2016

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“…While this work focuses on laser ablation in brain, there are diverse organs that receive laser ablation at various levels of clinical maturity, including breast (69), liver (70), pancreas, prostate (71), and spine (72, 73), sometimes with therapeutic enhancing agents, e.g., nanoparticles and dyes (74–76). At this time, it is not clear to the authors whether or not the proposed steady state model within a train-and-predict paradigm is widely applicable to other body sites.…”

Section: Discussionmentioning

confidence: 99%

Theoretical model for laser ablation outcome predictions in brain: calibration and validation on clinical MR thermometry images

Fahrenholtz

Madankan

Danish

et al. 2017

International Journal of Hyperthermia

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“…μg Au/ml). These ideas have already been applied to thermal therapy of tumors with perfusion using computational approaches (48; 49). Here we expand the applications for nanoparticle heating into tissue cryopreservation, diagnostics, and fish embryo rewarming (15; 16; 27).…”

Section: Nanoparticle Heatingmentioning

confidence: 99%

From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer

Bischof

Diller

2018

Annu. Rev. Biomed. Eng.

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This review explores bioheat transfer applications at multiple scales from nanoparticle (NP) heating to whole-body thermoregulation. For instance, iron oxide nanoparticles are being used for nanowarming, which uniformly and quickly rewarms 50-80-mL (≤5-cm-diameter) vitrified systems by coupling with radio-frequency (RF) fields where standard convective warming fails. A modification of this approach can also be used to successfully rewarm cryopreserved fish embryos (∼0.8 mm diameter) by heating previously injected gold nanoparticles with millisecond pulsed laser irradiation where standard convective warming fails. Finally, laser-induced heating of gold nanoparticles can improve the sensitivity of lateral flow assays (LFAs) so that they are competitive with laboratory tests such as the enzyme-linked immunosorbent assay. This approach addresses the main weakness of LFAs, which are otherwise the cheapest, easiest, and fastest to use point-of-care diagnostic tests in the world. Body core temperature manipulation has now become possible through selective thermal stimulation (STS) approaches. For instance, simple and safe heating of selected areas of the skin surface can open arteriovenous anastomosis flow in glabrous skin when it is not already established, thereby creating a convenient and effective pathway to induce heat flow between the body core and environment. This has led to new applications of STS to increase or decrease core temperatures in humans and animals to assist in surgery (perioperative warming), to aid ischemic stress recovery (cooling), and even to enhance the quality of sleep. Together, these multiscale applications of nanoparticle heating and thermoregulation point to dramatic opportunities for translation and impact in these prophylactic, preservative, diagnostic, and therapeutic applications of bioheat transfer.

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Development of a computational simulation tool to design a protocol for treating prostate tumours using transurethral laser photothermal therapy

Cited by 42 publications

References 43 publications

Thermal Scanning at the Cellular Level by an Optically Trapped Upconverting Fluorescent Particle

Thermal Scanning at the Cellular Level by an Optically Trapped Upconverting Fluorescent Particle

Theoretical model for laser ablation outcome predictions in brain: calibration and validation on clinical MR thermometry images

From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer

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